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2009 Molecular Parasitology
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2009 Molecular Parasitology: Accepted Abstracts
Abstracts are listed alphabetically by title; use the links below to jump to the
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* = presenting author
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A
A complete tricarboxylic acid cycle is not required in P. falciparum blood stage parasites
Ke, Hangjun [1] , Mather, Michael W. [1] , Olszewski, Kellen [2] , Maddur Ganesan, Suresh [1] , Morrisey, Joanne M [1] , Llinas, Manuel [2] , Vaidya, Akhil B [*,1]
1. Center for Molecular Parasitology, Drexel Univ. College of Medicine, Philadelphia, PA, USA
2. Dept. of Molecular Biology, Princeton Univ, Princeton, NJ, USA
A conserved family of proteins reveals novel compartments and hierarchical targeting behavior in the Toxoplasma gondii Inner Membrane Complex
Beck, Josh , Rodriguez, Imilce , Bradley, Peter [*]
MIMG, UCLA, Los Angeles, CA, USA
A Critical Human Chromosomal Locus Associated with Susceptibility/Resistance to Toxoplasma gondii Infection
Hypolite, Magali Sarah [1] , Liu, Susan [1] , Mui, Ernest J. [1] , Fournie, Gilbert J [2] , Bisanz, Cordelia [3] , Cavailles, Pierre [3] , Cesbron-Delauw, Marie-France [3] , Witola, William Harold [1] , McLeod, Rima [*,1]
1. Ophthalmology and Visual Sciences, University of Chicago, Chicago, IL, USA
2. Centre de physiopathologie de Toulouse Purpan, Toulouse, France
3. University of Joseph Fourier, La Tronche, France
A genome-scale, cell-based screen in Toxoplasma gondii infected cells identifies positive regulators of STAT1-mediated transcription
Beiting, Daniel P [1] , Geskes, Jeanne [2] , Baggs, Julie E [2] , Hogenesch, John B [2] , Cherry, Sara [3] , Roos, David S [*]
1. Biology, University of Pennsylvania, philadelphia, PA, USA
2. School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
3. Microbiology, University of Pennsylvania, Philadelphia, PA, USA
A La autoantigen homologue in Giardia lamblia is required for Giardiavirus internal ribosome entry site mediated translation initiation
Garlapati, Srinivas , Wang, Ching C [*]
Pharamceutical Chemistry, University of California San Francisco, San Francisco, CA, USA
A Model For Chloroquine Transport in Live Malaria
Paguio, Michelle F [1] , Cabrera, Mynthia [2] , Roepe, Paul David [*,1]
1. Biochemistry, Cell. & Mol. Biol., Georgetown University, Washington, DC, USA
2. Georgetown University, Washington , DC, USA
A New Model of Hemoglobin Transport in the Human Malaria Parasite, Plasmodium falciparum
Hahn, Katharine , Schneider, Timothy , Taraschi, Theodore F [*]
Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
A new toxolysin plays an important role in the Toxoplasma gondii lytic cycle.
Laliberte, Julie [*] , Carruthers, Vernon Bruce
Immunology and Microbiology, University of Michigan, Ann Arbor, MI, US
A novel exported protein in Plasmodium falciparum localizes to recently described tethers
Pachlatko, Esther M [1] , Mueller, Anouk [1] , Hemphill, Andrew [2] , Chiappe, Diego [3] , Moniatte, Marc [3] , Klonis, Nectarios [4] , Tilley, Leann [4] , Hanssen, Eric [4] , Beck, Hans-Peter [*,1]
1. Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
2. Institute of Parasitology, University of Bern, Bern, Switzerland
3. EPFL Proteomics Core Facility, School of Life Sciences, Ecole Politechnique Fédérale de Lausanne, Lausanne, Switzerland
4. Department of Biochemistry and ARC Centre of Excellence for Coherent X-ray Science, La Trobe University, Melbourne, Australia
A novel myosin light chain partner in Plasmodium
Chatterjee, Kasturi , Daly, Thomas M, Bergman, Lawrence W [*]
Microbiology and Immunology, Drexel University College of Medicine, philadelphia, PA, USA
A novel phosphoglucomutase (PGM) of Giardia lamblia has both PGM and phosphomannomutase activities
Mitra, Sanghamitra , Cui, Jike , Robbins, Phillips W. , Samuelson, John [*]
Department of Molecular and Cell Biology, Boston University , Boston, MA, USA
A novel Plasmodium yoelii locus for stable trans-gene expression and complementation
Jacobs-Lorena, Vanessa Y, Mikolajczak, Sebastian A, Labaied, Mehdi , Vaughan, Ashley M, Kappe, Stefan HI [*]
Seattle Biomedical Research Institute, Seattle, WA, USA
A novel preribosomal particle in Trypanosoma brucei
Ciganda, Martin , Williams, Noreen [*]
Microbiology, University at Buffalo, Buffalo, NY, USA
A novel TOR kinase in Leishmania is responsible for acidocalcisome function and virulence in mice
Madeira da Silva, Luciana , Beverley, Stephen M [*]
Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States of America
A Plasmodium falciparum ApiAP2 protein binds specifically to DNA motifs in subtelomeric repeats and var upstream regions
Flueck, Christian [1] , Bártfai, Richard [2] , Niederwieser, Igor [1] , Alako, Blaise [2] , Moes, Suzette [3] , Bozdech, Zbynek [4] , Jenoe, Paul [3] , Stunnenberg, Hendrik G [2] , Voss, Till S [*,1]
1. Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
2. Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands, Nijmegen, The Netherlands
3. University of Basel, Biozentrum, Basel, Switzerland, Basel, Switzerland
4. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, Singapore
A proteomic analysis of a Golgi-associated bi-lobed structure in Trypanosoma brucei
Zhou, Qing , Lin, Qingsong , He, Cynthia Y [*]
Biological Sciences, National University of Singapore, Singapore, Singapore
A putative ortholog of UIS4 in Plasmodium falciparum does not complement UIS4 function in the liver stage of P. yoelii
MacKellar, Drew , Aly, Ahmed , Kappe, Stefan [*]
Seattle Biomedical Research Institute, Seattle, WA, USA
A screen for potential epigenetic regulatory proteins reveals nuclear sub-compartments and potential candidates for virulence gene control in Plasmodium falciparum
Volz, Jennifer [1] , Carvalho, Teresa G [1] , Ralph, Stuart A [2] , Gilson, Paul [3] , Thompson, Jenny [1] , Tonkin, Christopher J [1] , Crabb, Brendan S [3] , Cowman, Alan F [*,1]
1. Infection and Immunity, Walter+Eliza hall Institute of Medical Research, Parkville, Melbourne; VIC, Australia
2. Biochemistry and Molecular Biology, Bio21, Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia
3. Burnet Institute, Melbourne, VIC, Australia
A small RNA derived from Giardia lambia snoRNA2 functions like a microRNA
Li, Wei , Wang, CC [*]
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA
A Toxoplasma dense granule protein mediates strain-specific activation of NF-kB
Rosowski, Emily , Lu, Diana , Wang, Yiding , Jensen, Kirk , Rodda, Lauren , Gaiser, Rogier , Julien, Lindsay , Polite, Markeiya , Saeij, Jeroen [*]
Biology, MIT, Cambridge, MA, USA
A Yeast Three-Hybrid system for target identification of small molecules that inhibit Toxoplasma gondii invasion
Fernandez Cuppari, Anahi V [1] , Pathak, Ravi [2] , Walton, Jeffrey GA [2] , Liu, Gu [2] , Poupart, Severine [2] , Westwood, Nicholas J [2] , Ward, Gary E [*,1]
1. Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA
2. School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Scotland
Activation of the Host Cell Transcription Factor Serum Response Factor by Toxoplasma gondii
Buechele, Megan , Blader, Ira [*]
Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Aggresome-like structures in the malaria parasite Plasmodium falciparum
Camarda, Grazia [*] , Bertuccini, Lucia , Olivieri, Anna , Alano, Pietro
Istituto Superiore di Sanita, Rome, Italy
Alba, a new role for an ancient archaebacterial DNA-binding protein in P. falciparum gene silencing
Scherf, Artur [1] , Riviere, Loic , Hernandez-Rivas, Rosaura [2]
1. Institut Pasteur, Paris, France
2. CINVESTAV, Mexico City, Mexico
Ally or Enemy? Role of Toll-Like Receptor 2 in Trypanosoma cruzi Infection
Nohara, Lilian L., Almeida, Igor C. [*]
Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA
Alternative oxidases in Perkinsus sp. : Characterization and evolutionary considerations
Leite, Ricardo B [*] , Afonso, Ricardo , Cancela, M. Leonor
FCT , CCMAR/University of Algarve, Faro, Portugal
AMP synthesis and fate of fumarate in Plasmodium falciparum
Bulusu, Vinay , Balaram, Hemalatha [*]
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
An Improved Ultrasensitive Method for PCR Based Detection of Plasmodium falciparum malaria
Rajapandi, Thavamani , Stedman, Timothy T [*]
MR4, ATCC, Manassas, VA, USA
An unexpected role of SIR2A in the life cycle of malaria parasites
Religa, Agnieszka [*,1] , Carret, Celine [2] , Feltwell, Theresa [3] , Hu, Guangan [4] , Amaladoss, Anburaj [4] , Brochet, Mathieu [3] , Pain, Arnab [3] , Bozdech, Zbynek [4] , Preiser, Peter [4] , Billker, Oliver [3] , Janse, Chris [*,1] , Scherf, Artur [5] , Waters, Andy [*,6]
1. Leiden University Medical Centre, Leiden, The Netherlands
2. Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal
3. The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
4. Nanyang Technological University, Singapore, Singapore
5. Institut Pasteur, Paris, France
6. University of Glasgow, Glasgow, United Kingdom
Anopheles aquasalis infected by Plasmodium vivax displays unique gene expression profiles when compared to other malaria vectors and plasmodia
Traub-Cseko, Yara M. [*,1] , Bahia, Ana C. [1] , Kubota, Marina S. [1] , Tempone, Antonio J. [1] , Pinheiro, Waleria D. [2] , Tadei, Wanderli T. [2] , Secundino, Nágila F.C. [3] , Pimenta, Paulo F.P. [3]
1. Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil
2. Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil
3. Instituto René Rachou, Fiocruz , Belo Horizonte, Brazil
Anti-apoptotic and inflammatory responses induced by Toxoplasma gondii infection are regulated distinctively by members of the host TLR family
Molestina, Robert E [*] , Cedrone, Edward , Glaser, Kathleen , Hagos, Biniam
ATCC, Manassas, VA, USA
B
Biochemical and deep sequencing approaches to delineate the RNA interference pathway in Leishmania (Viannia) braziliensis
Atayde, Vanessa D [*,1] , Shi, Huafang [1] , Franklin, Joseph B [2] , Norton, Tim [3] , Lye, George [3] , Owens, Katherine [3] , Beverley, Stephen M [3] , Tschudi, Christian [4] , Ullu, Elisabetta [5]
1. Internal Medicine, Yale University, New Haven, CT, USA
2. Cell Biology, Yale University, New Haven, CT, USA
3. Molecular microbiology, Washington University School of Medicine, St Louis, MO, USA
4. Epidemiology and Public Health, Yale University, New Haven, CT, USA
5. Internal Medicine and Cell Biology, Yale University, New Haven, CT, USA
Biochemical and Genetic Analysis of Quinoline Resistance in Plasmodium falciparum
Mayer, Sybille [1] , Nurhasanah, Astutiati [1] , Sanchez, Cecilia P [1] , Stein, Wilfred D [2] , Lanzer, Michael [*,1]
1. Department of Parasitology, University of Heidelberg, Heidelberg, Germany
2. Biological Chemistry, Silberman Institute of Life Sciences, Jerusalem, Israel
Biochemical characterisation of lipoic acid protein ligase A1, an essential protein of Plasmodium falciparum
Storm, Janet [*] , Günther, Svenja , Müller, Sylke
Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, UK
Biochemical Studies of Plasmodium falciparum Lipoate Synthase
Gisselberg, Jolyn Elizabeth [1] , Booker, Squire J. [2] , Prigge, Sean T. [*,3]
1. Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA
2. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA
3. Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA
B
Bioinformatics and functional characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum
Tuteja, Renu [*]
Malaria Group, ICGEB, New Delhi, India
C
Calreticulin: a candidate receptor in Entamoeba histolytica phagocytosis
Vaithilingam, Archana , Huston, Christopher D [*]
University of Vermont, Burlington, VT, USA
Cell cycle analysis of Giardia intestinalis
Troell, Karin [*,1] , Jerlstrom-Hultqvist, Jon [2] , Ankarklev, Johan [2] , Karlsson, Erik [3] , Bernander, Rolf [3] , Svard, Staffan [2]
1. Dept of Virology, Immunobiology and Parasitology, National Veterinary Institute, Uppsala, SWEDEN
2. Dept of Cell and Molecular Biology, Uppsala Univeristy, Uppsala, Sweden
3. Dept of Molecular Evolution, Uppsala University, Uppsala, Sweden
Cell-based RNAi screens in the malaria vector Anopheles gambiae identify new regulators of host/pathogen interactions
Lombardo, Fabrizio [*] , Ghani, Yasmeen , Kafatos, Fotis C, Christophides, George K
Cell and Molecular Biology, Imperial College London, London, United Kingdom
Changes in histone modifications and chromatin accessibility are linked to the variant expression of the P. falciparum invasion gene PfRh4
Coleman, Bradley I., Duraisingh, Manoj T. [*]
Immunology & Infectious Disease, Harvard School of Public Health, Boston, MA, USA
Characterization of a cathepsin B-like protease (TgCPB) in maturation of microneme proteins in Toxoplasma gondii
Dou, Zhicheng , Laliberte, Julie , Thomas, Marsha , Strickler, Sarah , Carruthers, Vern B [*]
Microbiology and Immunology, The University of Michigan, Ann Arbor, MI, USA
Characterization of a malaria luminescence-based liver stage drug sensitivity screen
Johnson, Jacob Daniel [*,1] , Harris , Erin E. [1] , Kopydlowski, Karen M. [2] , Hudson, Thomas H. [1] , Kozar, Michael P. [1] , ONeil, Michael T. [*,1]
1. Parasitology, WRAIR, Silver Spring, MD, USA
2. USAMMDA, Fort Detrick, USA
Characterization of a Plasmodium falciparum Protein of Unknown Function
Butler, Tamira K, Goldberg, Daniel E [*]
Molecular Microbiology, Washington University in St Louis, Saint Louis, MO, United States
Characterization of an unc-51 related kinase (ULK) in Toxoplasma gondii
Ghosh, Debasish , Walton, Julia , El-Guendy, Nadia , Sinai, Anthony P [*]
Microbiology, Immunology, Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, USA
Characterization of Interactors of Plasmodium CDK-like kinases
Pease, Brittany , Schaefer, Logan , Ayong, Lawrence , Chakrabarti, Debopam [*]
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA
Characterization of MAL13P1.319, a Plasmodium falciparum sporozoite gene
Roberts, Renee N. [*,1] , Kariuki, Michael [1] , LaCrue, Alexis [2] , Schlarman, Maggie [1] , Ou, Ruguang [1] , Beerntsen, Brenda [1]
1. Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO, USA
2. Dept. of Global Health, University of South Florida, Tampa, FL, USA
Characterization of SERA proteases in blood stage of Plasmodium yoelii
Liew, Jiin Liang , Huang, Ximei , Preiser, Peter Rainer [*]
School of Biological Sciences, Nanyang Technological Univerisity, Singapore, Singapore
Characterization of the putative myosin light chains’ repertoire in Apicomplexa and functional analysis of GAP45
Polonais, Valerie [*,1] , Frenal, Karine [1] , Foth, Bernardo J [2] , Soldati, Dominique [1]
1. Department of Microbiology and Molecular Medicine, CMU, Geneva 4, Switzerland
2. Nanyang Technological University, Singapore 637551, Singapore
Characterization of the URE3-BP-regulated Entamoeba histolytica membrane protein GPI-1A
Gilchrist, Carol A [*] , Bousquet, Christina B., Moore, Ellyn S., Petri Jr., William A.
Department of Medicine, University of Virginia, Charlottesville, VA, USA
Characterizing the Host Response to Infection with Perforin-Like Protein 1-deficient Toxoplasma Tachyzoites
Kafsack, Bjorn F. C. [*,1] , Commodaro, Alessandra G. [2] , Hugunin, Kelly M. S. [3] , Eaton, Kathryn [3] , Rizzo, Luiz V. [4] , Pena, Janethe D. O. [5] , Carruthers, Vern B. [1]
1. Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
2. Vision Institute, Federal University of Săo Paulo, Săo Paulo, Brazil
3. Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
4. Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, Brazil
5. Department of Immunology, Universidade Federal de Uberlandia, Uberlandia, Brazil
Characterizing the Role of Parasite-Specific RNA-Binding Proteins During the Plasmodium falciparum Intraerythrocytic Development Cycle
Sarry, Louis R [*] , Llinás, Manuel
Molecular Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
Comparative transcriptomics of human and rodent malaria parasites
Amaladoss, Anburaj [1] , Mok, Sachel [2] , Hu, Guangan [2] , Liew, Kingsley [2] , Bozdech, Zbynek [2] , Preiser, Peter R [*,2]
1. Singapore MIT Alliance for Research & Technology (SMART), Singapore, Singapore
2. Nanyang Technological University, Singapore, Singapore
Computational Approaches to Identification of Apicomplexan Ligands
Hawley, Eric [1] , Tripathi, Abhishek [1] , Emrich, Scott [2] , Hager, Kristin M [*,1]
1. Biological Sciences, University of Notre Dame, NOTRE DAME, IN, UNITED STATES
2. Computer Science, University of Notre Dame, NOTRE DAME, IN, UNITED STATES
D
Deciphering the Function of Cactin in the Cell Cycle of Toxoplasma gondii
Szatanek, Tomasz Artur [1] , White, Michael [2] , Gubbels, Marc-Jan [*,1]
1. Biology, Boston College, Chestnut Hill, MA, United States
2. Molecular Medicine, University of South Florida, Tampa, FL, United States
Defining the molecular bridge between Toxoplasma invasion machinery and the host cell
Tyler, Jessica S. [*] , Boothroyd, John C.
Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
Delivery of P. falciparum proteins to the membrane of Maurer’s cleft, a secretory compartment transposed by the parasite in the cytoplasm of its host cell
Berry, Laurence , Mbengue, Alassane , Fall, Gamou , Braun Breton, Catherine [*]
Health and Biology, University Montpellier 2, Montpellier, France
Demonstration of a Leishmania Sexual Cycle in the Sand Fly Vector
Beverley, Stephen M. [*,1] , Akopyants, Natalia [1] , Kiimblin, Nicola [2] , Patrick, Rachel [2] , Secundino, Nagila [2] , Lawyer, Phillip [2] , Dobson, Deborah E. [1] , Sacks, David [2]
1. Molecular Microbiology, Washington University School of Medicine, St. Louis , USA
2. Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA
Determinants of Gene Expression Variation in Plasmodium falciparum
Siwo, Geoffrey H, Tan, Asako , Ferdig, Michael T [*]
Biological Sciences, University of Notre Dame, Notre Dame, IN, USA
Development of a system to assess in situ switching in the Babesia bovis locus of active ves transcription (LAT)
Wang, Xinyi , Allred, David R [*]
Infectious diseases, University of Florida, Gainesville, FL, United States
Development of activity-based probes for elucidating P. falciparum metallo-aminopeptidase function
Harbut, Michael , Velmourougane, Geetha , Reiss, Gilana , Greenbaum, Doron [*]
Pharmacology, University of Pennsylvania, Philadelphia, PA, United States
Development of RNA interference in parasitic nematodes
Huang, Stanley Ching-Cheng, Selkirk, Murray E. [*]
Division of Cell & Molecular Biology, Imperial College London, London, UK
Differential dynamics of two novel Plasmodium falciparum Inner Membrane Complex proteins throughout schizogony
Cabrera, Ana , Kono, Maya , Engelberg, Klemens , Herrmann, Susann , Spielmann, Tobias , Gilberger, Tim [*]
Bernhard-Nocht Institute for Tropical Medicine, Hamburg, Germany
Differential transcript expression between the microfilariae of the filarial nematodes, Brugia malayi and B. pahangi
Kariuki, Michael M [1] , Hearne, Leonard B [2] , Beerntsen, Brenda T [*,1]
1. Veterinary Pathobiology, University of Missouri, Columbia, MO, United States of America
2. Department of Statistics, University of Missouri, Columbia, MO, United States of America
Differentiation between Entamoeba histolytica, E. dispar and E. moshkovskii using pyrosequencing and prevalence analysis of E. moshkovskii in patients positive for the ‘Entamoeba complex’ diagnosed in Northwestern Europe
Stensvold, Christen R [*,1] , Lebbad, Marianne [2] , Verweij, Jaco J [3] , Geedi, Venkata RS [1] , Jensen, Jřrgen S [4] , Jespersgaard, Cathrine [5] , Samson-Himmelstjerna, Georg v. [6] , Nielsen, Henrik V [1]
1. Dept. of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen S, Denmark
2. Smittskydssinstitutet, Stockholm, Sweden
3. Leiden University Medical Center, Leiden, The Netherlands
4. Statens Serum Institut, Copenhagen , Denmark
5. Statens Serum Institut, Copenhagen S, Denmark
6. Hannover Institut für Parasitologie, Hannover, Germany
Dimerization is important for the interaction of P. vivax Duffy Binding Protein with the host receptor Duffy Antigen Receptor for Chemokines
Tolia, Niraj H [*]
Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA
Dipeptidyl Peptidases as Anti-Malarial Drug Targets: Validation and Drug Development
Deu Sandoval, Edgar [1] , Leyva, Melissa [2] , Ellman, Jonatthan A [1] , Bogyo, Matthew [*,1]
1. Pathology, Stanford School of Medicine, Stanford, CA, USA
2. Chemistry, UC Berkeley, Berkeley, CA, USA
Direct synthesis of cycloguanil and mislocalization of mitochondrial dihydrofolate reductase-thymidilate synthase (DHFR-TS) in atovaquone-proguanil treated P. falciparum
Fowble, Joseph W [1] , Li, Ling [2] , McLean, Jeremy E [1] , Pendyala, Prakash [1] , White, John [1] , Gardner, Malcolm [2] , Rathod, Pradipsinh K [*,1]
1. Chemistry, University of Washington, Seattle, WA, USA
2. Seattle Biomedical Research Institute, Seattle, WA, USA
Discovery of the malaria translocon for export of proteins into the host erythrocyte
de Koning-Ward, Tania F [*,1] , Gilson, Paul [2] , Boddey, Justin [3] , Rug, Melanie [3] , Smith, Brian [3] , Papenfuss, Anthony [3] , Sanders, Paul [3] , Lundie, Rachel [3] , Maier, Alexander [3] , Cowman, Alan [3] , Crabb, Brendan [2]
1. School of Medicine, Deakin University, Waurn Ponds, Australia
2. The Burnet Institute, Melbourne, Australia
3. The Walter & Eliza Hall Institute , Parkville, Australia
Disruption of lipoylation in the P. falciparum mitochondrion is lethal
Spalding, Maroya D [1] , Prigge, Sean T [*,2]
1. Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA
2. Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Disruption of PfPuf1 in Plasmodium falciparum reduces gametocytegenesis
Cui, Long , Miao, Jun , Cui, Liwang [*]
The Pennsylvania State University, University Park, PA, USA
Dissecting the Role of ApiAP2 DNA Binding Proteins
Campbell, Tracey L, De Silva, Erandi K, Painter, Heather J, Llinás, Manuel [*]
Molecular Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
Dmc1 (a meiotic recombinase) deficient Plasmodium berghei parasites are delayed in their sexual development in the mosquito vector.
Mlambo, Godfree , Coppens, Isabelle , Kumar, Nirbhay [*]
Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA
DNA Mismatch Repair in Plasmodium Falciparum: A Potential Mechanism for Antimalarial Drug Resistance
Castellini, Meryl A [1] , Buguliskis, Jeff S [2] , Casta, Lou J [3] , Butz, Charles E [1] , Clark, Alan [4] , Kunkel, Thomas [4] , Taraschi, Theodore F [*,1]
1. Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
2. Washington University at St. Louis, St. Louis, MO, USA
3. Fraunhofer Center for Molecular Biotechnology, Newark, DE, USA
4. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Drug Discovery Space for African Sleeping Sickness, Chagas Disease, and Visceral Leishmaniasis
McAllister, Gregory [1] , Al-Lazikani, Bissan [2] , Overington, John P [2] , Chellammal, Sivagamy [1] , Pollastri, Michael P [3] , Campbell, Robert K [*,1]
1. Josephine Bay Paul Center in Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA, USA
2. ChEMBL Group, EMBL-EBI, European Bioinformatics Institute, Hinxton, United Kingdom
3. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA
E
Effect of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus
Zimmermann , Luciana T [1] , Folly, Evelize [2] , Alviano, Daniela S [1] , Silva-Filho , Fernando C [3] , Atella, Georgia C [4] , Gomes, Marta T [5] , Lopes, Angela H [*,1]
1. Microbiology, Federal University of Rio de Janeiro, Brazil, Rio de Janeiro, Brazil
2. Biochemistry, Federal University of Rio de Janeiro, Brazil, Rio de Janeiro, Brazil
3. Biophysics, Federal University of Rio de Janeiro, Brazil, Rio de Janeiro, Brazil
4. Federal University of Rio de Janeiro, Brazil, Rio de Janeiro, Brazil
5. Microbiology, Federal University of Rio de Janeiro, Brazil, Rio de Janeiro, Brazil
EhMSP-1, an antigenic E. histolytica surface protein with homology to the immunodominant Leishmania protein leishmanolysin
Teixeira, Jose Eduardo, Huston, Christopher D [*]
University of Vermont, Burlington, VT, USA
Elucidating the post-translational ubiquitination machinery within the Plasmodium falciparum
Chung, Doug Duk-Won, Prudhomme, Jacques , Le Roch, Karine [*]
Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA, USA
Elucidating the Role of NAD+ Metabolism during Plasmodium falciparum Asexual Development
OHara, Jessica , Llinás, Manuel [*]
Department of Molecular Biology and Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, United States
Enhanced-expression and Inhibition Kinetics of Thymidylate Synthase from Filarial Nematode Brugia malayi
Nualnoi, Teerapat - [1] , Choochote, Wej - [2] , Wongkamchai, Sirijit - [3] , Canyuk, Bhutorn - [*,1]
1. Pharmaceutical Chemistry, Prince of Songkla University, Songkhla, Thailand
2. Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3. Faculty of Medicine-Siriraj Hospital, Mahidol University, Bangkok, Thailand
Entamoeba histolytica acidic intracellular vesicles as delivery vehicles for effectors of host cell death
Ralston, Katherine S., Petri, William A., Jr. [*]
Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA
EuPathDB: an integrated eukaryotic pathogen genome resource
Harb, Omar S [*,1] , Brunk, Brain [*,1] , -, For the EuPathDB Team [2]
1. Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA, USA
2. University of Georgia, Athens, GA, USA
Evidence of Sexual Recombination in Toxoplasma gondii Isolates Obtained from Pork in USA
Natarajan, Sundar [*,1] , Dubey, Jitender Prasad [2] , Grigg, Michael [1]
1. Laboratory of Parasitic Diseases,NIAID, National Institute of Health, Bethesda, MD, USA
2. USDA, Beltsville, MD, USA
Exflagellation of the Plasmodium berghei male gametocyte is dependent on the function of the second actin
Siden-Kiamos, Inga [*,1] , Deligianni, Elena [1] , Morgan, Rhiannon [1] , Bertuccini, Lucia [2] , Laforge, Alice [1] , Louis, Christos [1] , Matuschewski, Kai [3]
1. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece
2. Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanitŕ, Rome, Italy
3. Parasitology Unit, Max Planck Institute for Infection Biology, Berlin, Germany
Exploring Host-Pathogen interactions of Toxoplasma gondii through the use of reverse genetics
Rommereim, Leah M, Fox, Barbara A, Bzik, David J [*]
Microbiology/Immunology, Dartmouth College, Lebanon, NH, United States
Exploring the role of the aminopeptidase N homolog PfA-M1 in the Plasmodium falciparum food vacuole
Ragheb, Daniel RT, Bompiani, Kristin , Klemba, Michael [*]
Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
Export of proteins without a PEXEL/VTS motif
Grüring, Christof , Heiber, Arlett , Gilberger, Tim-Wolf , Spielmann, Tobias [*]
Molecular Parasitology, Bernhard Nocht Institute Hamburg, Hamburg, Germany
Expression of dominant negative mutants to unravel the functions of rhomboid proteases in Toxoplasma gondii
Santos, Joana M. [*,1] , Sheiner, Lilach [1] , Dowse, Tim [1] , Blackman, Michael J. [2] , Soldati-Favre, Dominique [1]
1. Microbiology, University of Geneva, geneva, switzerland
2. Parasitology, National Institute for Medical Research, London, UK
Expression of PfNPL4 in erythrocytic stages of Plasmodium falciparum
Dahan-Pasternak, Noa , Ron, Dzikowski [*]
Microbiology & Molecular Genetics, Hebrew University , Jerusalem, Israel
Extracellular signal-regulated kinase (ERK) activation from Leishmania amazonensis-containing parasitophorous vacuoles
Boggiatto, Paola M [1] , Jones, Douglas E [1] , Bellaire, Bryan [2] , Petersen, Christine A [*,1]
1. Immunobiology-Veterinary Pathology, Iowa State University, Ames, IA, USA
2. Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA
F
Fast elastic ejection of malaria parasites from erythrocytes
Braun Breton, Catherine [*,1] , Massiera, Gladys [2] , Berry, Laurence [1] , Roques, Magali [2] , Abkarian, Manouk [2]
1. Health and Biology, University Montpellier 2, Montpellier, France
2. Physics, University Montpellier 2, Montpellier, France
Fluorescence Imaging with Simultaneous Transmitted Light Based Tracking and Customized High-Throughput Acquisition of Trypanosoma brucei
Gniadek, Thomas J [*,1] , Sealey-Cardona, Marco [2] , Warren, Graham [2]
1. Cell Biology, Yale University, New Haven, CT, USA
2. Max F Perutz Laboratories GmbH, Vienna, Austria
Functional analyses of a novel sortilin-related receptor in Toxoplasma gondii
Sloves, Pierre Julien , Tomavo, Stanislas [*]
CNRS UMR 8161-Institut de Biologie de Lille, Institut Pasteur de Lille, Lille, France
Functional analyses of the Tetraspanin 6 membrane protein during Trichomonas vaginalis migration and pathogenesis
de Miguel, Natalia , Riestra, Angelica , Johnson, Patricia J [*]
University of California, Los Angeles, Los Angeles, CA, USA
Functional Analysis of A Putative Cysteine Protease Receptor From Entamoeba Histolytica
Furukawa, Atsushi , Nakada-Tsukui, Kumiko , Yamada, Yoko , Nozaki, Tomoyoshi [*]
Parasitology, National Institute of Infection Diseases, Shinjuku-ku, Tokyo, Japan
Functional analysis of the hexose transporter in Plasmodium spp.
Slavic, Ksenija [1] , Xu, Zhengyao [2] , Straschil, Ursula [3] , Doerig, Christian [4] , Tewari, Rita [*,2] , Krishna, Sanjeev [*,1]
1. Cellular and Molecular Medicine , St. Georges University of London, London, United Kingdom
2. The University of Nottingham, Nottingham, United Kingdom
3. Imperial College, London, United Kingdom
4. University of Glasgow, Glasgow, United Kingdom
Functional analysis of Toxoplasma gondii type II NADH dehydrogenases
Lin , San San [*] , Gross , Uwe , Bohne, Wolfgang [*]
Institute of Medical Microbiology, University of Goettingen, Goettingen, Germany
Functional characterization of a conserved set of malaria antigens
Mantel, Pierre-Yves , Refour, Philippe , Duraisingh, Manoj , Marti, Matthias [*]
Harvard School of Public Health, Boston, MA, USA
Functional characterization of a newly proposed malaria blood-stage vaccine candidate
Kulangara, Caroline [1] , Corradin, Giampietro [2] , Felger, Ingrid [*,1]
1. Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
2. Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Functional dissection of the L. major LACK protein
Choudhury, Kohelia [1] , Lapara III, Nicholas J [2] , Kelly, Ben L [*,1]
1. Microbiology, Immunology and Parasitology, Louisiana State University , New Orleans, LA, United States
2. Microbiology, Immunology and Parasitology, LSU Health Sciences Center , New Orleans, LA, United States
Functional Genomic / Metabolomic Analysis of Glycolysis in Toxoplasma gondii: Glucose is not an essential nutrient!
Shanmugam, Dhanasekaran [1] , Olszewski, Kellen L [2] , Ilinas, Manuel [2] , Beiting, Daniel [1] , Fox, Barbara A [3] , Rommereim, Leah M [3] , Bzik, David J [3] , Xia, Dong [4] , Wastling, Jonathan M [4] , Roos, David S [*,1]
1. Univ. of Pennsylvania, Philadelphia, PA, USA
2. Princeton Univ., Princeton, NJ, USA
3. Dartmouth Medical School, Lebanon, NH, USA
4. Univ. Liverpool, Liverpool, UK
G
Gene expression of putative antioxidant genes in the early mosquito stages of Plasmodium berghei
Russo, Linda [1] , Kawazu, Shin-Ichiro [2] , Kanzok, Stefan M [*,1]
1. Biology, Loyola University Chicago, Chicago, IL, USA
2. National Research Center for Protozoan Diseases, University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Genetic analyses of virulence and host resistance to toxoplasmosis
Sibley, David [*,1] , Fentress, Sarah [1] , Dunay, Ildiko [1] , Khan, Asis [1] , Alaganan, Aditi [1] , Tang, Keliang [1] , Qiu, Wei [2] , Hui, Ray [2] , Zhao, Zijiang [3] , Virgin, Herbert W. [3]
1. Dept. Molec. Micro., Washington University Sch. Med., St. Louis, MO, USA
2. Univ. Toronto, Toronto, Canada
3. Pathology and Immunology, Washington Univ. Sch. med., St. Louis, USA
Genetic and Immunogenic Characterisation of the Plasmodium falciparum Rhoptry Neck Protein PfRON4
Morahan, Belinda J, Sallmann, Georgina B, Huestis, Robert , Dubljevic, Valentina , Waller, Karena [*]
Microbiology, Monash University, Clayton VIC, Australia
Genetic Dissection of the Accelerated Acquisition of Drug Resistance in ARMD Plasmodium falciparum
Freeman, Dan L, White, John , Gujjar, Ramesh , Ganesan, Karthikeyan , Rathod, Pradipsinh K [*]
Department of Chemistry and Global Health, University of Washington, Seattle, WA, USA
Genetic dissection of Toxoplasma gondii
Bzik, David J. [*,1] , Fox, Barbara A. [2] , Rommereim, Leah M. [2]
1. Microbiology and Immunology, Dartmouth Meidcal School, Lebanon, NH, USA
2. Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA
Genetic diversity of Toxoplasma gondii infecting Pacific coastal wild birds
Miller, Robin H. [1] , Nandra, Amandeep [2] , Stitt, Tyler [3] , Bowie, William [2] , Stephen, Craig [3] , Grigg, Michael E. [*,1]
1. Laboratory of Parasitic Diseases, National Institutes of Health , Bethesda, MD, USA
2. Departments of Medicine and Microbiology & Immunology, University of British Columbia, Vancouver, Canada
3. Malaspina University, Nanaimo, Canada
Genome and transcriptome sequence of the apicomplexan parasite Neospora caninum
Reid, Adam J [*,1] , Sohal, Amandeep [1] , Harris, David [1] , Norton, R [2] , Latham, S [2] , Quail, Michael [1] , Berriman, Matthew [1] , Wastling, Jonathan M [2] , Pain, Arnab [1]
1. Wellcome Trust Sanger Institute, Cambridge, UK
2. University of Liverpool, Liverpool, UK
Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding regions and histone free transcription start sites and chromatin remodeling of core and subtelomeric genes
Westenberger, Scott J [*,1] , Cui, Long [2] , Dharia, Neekesh V [1] , Winzeler, Elizabeth A [1] , Cui, Liwang [2]
1. Cell Biology, The Scripps Research Institute, La Jolla, CA, United States
2. Dept of Entomology, Pennsylvania State University, University Park, PA, United States
Global profiling of proteolytic events prior to rupture of P. falciparum from the eyrthrocyte
Bowyer, Paul W [1] , Simon, Gabriel M [2] , Cravatt, Benjamin F [2] , Bogyo, Matthew S [*,1]
1. Pathology, Stanford University School of Medicine, Stanford, CA, USA
2. Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA
H
High content RNAi screen for host factors that affect phagocytosis of Leishmania donovani amastigotes
Peltan, Adam [*,1] , Briggs, Laura [2] , Matthews, Gareth [1] , Sweeney, Sean [2] , Smith, Deborah [1]
1. Dept. of Biology and Hull York Medical School, University of York, York, UK
2. Dept. of Biology, University of York, York, UK
High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery
Cervantes, Serena S [1] , Prudhomme, Jacques [1] , Carter, David [2] , Gopi, Krishna G [3] , Li, Qian [4] , Chang, Young-Tae [3] , Le Roch, Karine G [*,1]
1. Cell Biology and Neuroscience, University of California Riverside, Riverside, CA, USA
2. University of California Riverside, Riverside, USA
3. National University of Singapore, Singapore, Singapore
4. New York University, New York, USA
Hi-Throughput Genomic Screens with Toxoplasma
Davis, Paul H [1] , Lee, Ming Yeh [1] , Hogenesch, John [2] , Roos, David S [*,1]
1. Biology, University of Pennsylvania, Philadelphia, PA, USA
2. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
Host lysosomes in Plasmodium bergei liver infection
Lopes-Silva, Mafalda [*] , Seabra, Miguel C
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Host siRNA Screening Identifies a Critical Role for Host Microtubules in Toxoplasma gondii Invasion
Sweeney, Kristin R [1] , Brown, Kevin M [1] , Morrissette, Naomi [2] , Blader, Ira J [*,1]
1. Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, Unites States
2. Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, United States
How does Toxoplasma gondii introduce virulence factors into the host cell during invasion?
Caffaro, Carolina [*,1] , Boothroyd, John [2]
1. Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, United States
2. Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, United States
I
Identification and characterization of atypical SNARE complexes in P. falciparum
Mauser, Jennifer , Ayong, Lawrence , Alvarado, Stephenie , Chakrabarti, Debopam [*]
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, United States
Identification and characterization of transcriptional regulators in Plasmodium
Kumar, Sumit , Daly, Thomas M, Bergman, Lawrence W [*]
Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
Identification of a dense granular protein induced and secreted by Toxoplasma gondii bradyzoites
Buchholz, Kerry R [*] , Boothroyd, John C.
Microbiology and Immunology, Stanford University, Stanford, CA, USA
Identification of essential host interaction factors for the Apicomplexan parasite Toxoplasma gondii using a forward genetic siRNA screen
Agop-Nersesian, Carolina B. [1] , Fuchs, Florian [2] , Breinich, Manuela S. [1] , Boutros, Michael [2] , Meissner, Markus [*,1]
1. Parasitology, Hygiene Institute, Medical School Heidelberg, Heidelberg, Germany
2. Boveri-Group Signaling and Funktional Genomics, German Cancer Research Center, Heidelberg, Germany
Identification of Methylated Loci in the Trypanosoma brucei Genome
Hennick, Stacy M, Jayakar, Sangeeta K, Jensen, Tina K, Militello, Kevin T [*]
Biology, State University of New York at Geneseo, Geneseo, NY, USA
Identifying novel genes involved in the Toxoplasma gondii Apicoplast biogenesis
sheiner, lilach [*,1] , Behnke, Michael S [2] , White, Michael W [2] , Striepen, Boris [1]
1. CTEGD, University of Georgia, Athens, GA, USA
2. Dept. of Molecular Medicine, USF, tampa, FL, USA
Identifying the Host Molecules that are Associated with the Pathogenesis of Cerebral Malaria
Oakley, Miranda Sarah Melissa [*,1] , Aravind, L. [2] , Kumar, Sanjai [3]
1. Division of Bacterial, Parasitic, and Allergenic Products, FDA, Bethesda, MD, USA
2. NCBI, NLM, NIH, Bethesda, MD, USA
3. Division of Emerging and Transfusion Transmitted Diseases, FDA, Bethesda, MD, USA
Illuminating the endogenous small interfering RNA pathway in Trypanosoma brucei by functional studies and deep sequencing
Tschudi, Christian [*,1] , Barnes, Rebecca [2] , Franklin, Joseph [2] , Kolev, Nikolay [1] , Patrick, Kristin [1] , Shi, Huafang [2] , Ullu, Elisabetta [2]
1. Yale University School of Public Health, New Haven, CT, USA
2. Yale University School of Medicine, New Haven, CT, USA
Impact of antimalarial drugs on gametocytogenesis
Adjalley, Sophie H, Fidock, David A [*]
Microbiology, Columbia University, New York, NY, USA
In Vivo Evaluation of Genetic and Pharmacological Targeting of the Leishmania donovani Polyamine Biosynthetic Pathway
Olenyik, Tamara D [1] , Roberts, Sigrid [2] , Ullman, Buddy [*,1]
1. Biochemisty and Molecular Biology, Oregon Health & Sciences University, Portland, OR, USA
2. Pacific University School of Pharmacy, Hillsboro, OR, USA
Individual cellular and biochemical activities of Plasmodium actin capping protein (CP) subunits
Ganter, Markus [1] , Schüler, Herwig [*,2] , Matuschewski, Kai [*,1]
1. Max Planck Institute for Infection Biology , Berlin, Germany
2. Karolinska Institute, Stockholm, Sweden
Inducible Myb3 nuclear translocation in the protozoan parasite Trichomonas vaginalis
Hsu, Hong-Ming , Dhamura, Indra , Liu, Hsing-Wei , Tai, Jung-Hsiang [*]
Division of infectious diseases, Institute of biomedical science, Academia Sinica, Taipei, Taiwan, Republic of China
Inhibition of PfAMA1 shedding enhances susceptibility of malaria merozoites to invasion-inhibitory antibodies
Olivieri, Anna [*] , Collins, Christine R, Blackman, Michael J
Parasitology, National Institute for Medical Research, London, United Kingdom
Interaction of exoerythrocytic Plasmodium berghei parasites with the hepatocyte plasma membrane and cytoskeleton
Rankin, Kathleen E [*] , Struck, Nicole S, Graewe, Stefanie , Heussler, Volker T [*]
Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Investigating the role of EBA-175 in Plasmodium falciparum moving junction
pal bhowmick, ipsita , Miller, Louis [*]
NIAID, NIH, rockville, MD, USA
Isolation of Plasmodium falciparum var genes using TAR cloning
Gaida, Annette [*,1] , Becker, Marion [2] , Louis, Ed [2] , Beck, Hans-Peter [1]
1. Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
2. Institute of Genetics, The University of Nottingham, Queen`s Medical Centre, Nottingham, England
K
Knockdown of a novel Plasmodium falciparum calcium-dependent protein kinase reveals an essential pathway for parasite egress from human erythrocytes
Dvorin, Jeffrey D, Duraisingh, Manoj T [*]
Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
L
Live imaging of organelle segregation in double-fluorescent Plasmodium berghei liver stage parasites
Stanway, Rebecca [*,1] , Froehlke, Ulrike [1] , Zobiak, Bernd [2] , Roppenser, Bernhard [2] , Aepfelbacher, Martin [2] , Heussler, Volker [1]
1. Molecular Parasitology, Bernhard Nocht Institute, Hamburg, Germany
2. Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
Localization and Characterization of Chitin present in the Marine Parasite Perkinsus olseni
Afonso, Ricardo [*,1] , Leite, Ricardo B [1] , Nunes, Cláudia [2] , Coimbra, Manuel A [2] , Gama, Miguel [3] , Cancela, M Leonor [1]
1. Center of Marine Sciences, University of Algarve, Faro, Portugal
2. Department of Chemistry, University of Aveiro, Aveiro, Portugal
3. Centre of Biological Engineering, Institute for Biotechnology and Bioengineering, Braga, Portugal
Looking for the red light: Analysis of parasite-host interactions during the liver stage of rodent malaria infections using novel red-fluorescent Plasmodium strains
Graewe, Stefanie [*] , Stanway, Rebecca R, Retzlaff, Silke , Rennenberg, Annika , Helm, Susanne , Struck, Nicole , Heussler, Volker T
Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
M
Malaria Programmed Cell Death: Pathways and Perspectives
Tan, Kevin SW [*,1] , Chng, Jun Hong [1] , Kumar, Kotturi Rajaiah Santosh [2] , Lear, Martin J [2]
1. Microbiology, National University of Singapore, Singapore, Singapore
2. Chemistry, National University of Singapore, Singapore, Singapore
Matching Drug Discovery Programs to Malaria
Campbell, Robert K [*,1] , Al-Lazikani, Bissan [2] , Overington, John P [2] , McAllister, Gregory [1] , Chellammal, Sivagamy [1] , Pollastri, Michael P [3]
1. Josephine Bay Paul Canter in Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA, USA
2. ChEMBL Group, EMBL-EBI, European Bioinformatics Institute, Hinxton, United Kingdom
3. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA
Mechanisms controlling developmental pathways in Entamoeba
Ehrenkaufer, Gretchen M, Singh, Upinder [*]
Microbiology and Immunology, Stanford University, Stanford, CA, USA
Metabolomic Quantitative Trait Loci Analysis Implicates the Plasmodium Chloroquine Resistance Transporter as a Small Peptide Transporter
Olszewski, Kellen L. [1] , Wacker, Mark A. [2] , Tan, Asako [2] , Rabinowitz, Joshua D. [3] , Ferdig, Michael T. [2] , Llinás, Manuel [*,1]
1. Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
2. Eck Family Center for Global Health and Infectious Disease, University of Notre Dame, Notre Dame, IN, USA
3. Chemistry & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
Mitochondrial Functions in Malaria Parasites During In Vivo Infection
Morrisey, Joanne M [*,1] , Maddur Ganesan, Suresh [1] , Burns, Jr., James M. [2] , Mather, Michael W. [1] , Vaidya, Akhil B. [1]
1. Center for Molecular Parasitology, Microbiology and Immunology, Drexel Univ. College of Medicine, Philadelphia, PA, USA
2. Microbiology and Immunology, Drexel Univ. College of Medicine, Philadelphia, PA, USA
Molecular Basis of Divergent Unstable Actins in Apicomplexan Parasites
Skillman, Kristen M. [*,1] , Diraviyam, Karthikeyan [2] , Tang, Keliang [1] , Sept, David [2] , Sibley, L. David [*,1]
1. Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, United States
2. Department of Biomedical Engineering, Center for Computational Biology, Washington University, St. Louis, MO, United States
Molecular Cloning, Expression and Inhibition Kinetics of Thymidylate Synthase from Parasitic Nematode Dirofilaria immitis
Canyuk, Bhutorn - [*,1] , Nualnoi, Teerapat - [1] , Sailasuta, Achariya - [2] , Saenphakdee, Kamalas [1] , Keyunratsami, Korkeaw - [1] , Tanthana, Chanpa [1]
1. Pharmaceutical Chemistry, Prince of Songkla university, Songkhla, Thailand
2. Faculty of Veterinary Sciences, Chulalongkorn University, Bangkok, Thailand
Molecular Mediators of Toxoplasma gondii Persistence in Macrophages
Skariah, Sini , Mordue, Dana [*]
Microbiology & Immunology, New York Medical College, Valhalla, NY, USA
Monoclonal antibodies against PfRH1 erythrocyte binding domain disrupt merozoite invasion
Gao, Xiaohong , Gunalan, Karthigayan , Yap, Shu Lin Sally , Yeo, Kim Pin , Huang, Ximei , Preiser, Peter [*]
School of Biological Sciences, Nanyang Technological University , Singapore, Singapore
Motility studies of malaria parasites using micro-patterned substrates
Hellmann, Janina Kristin [*,1] , Münter, Sylvia [1] , Schwarz, Ulrich [2] , Spatz, Joachim [3] , Frischknecht, Friedrich [1]
1. Parasitology, Hygiene, Heidelberg, Germany
2. Zoology, Karlsruhe, Germany
3. Biophysical Chemistry, Heidelberg, Germany
mRNA decay is critical for intra-erythrocytic development of Plasmodium falciparum
Balu, Bharath , Maher, Steven P, Chauhan, Chitra , Adams, John H [*]
Global Health, University of South Florida, Tampa, FL, USA
N
Novel Antimalarials from Marine Natural Products
Alvarado, Stephenie [1] , Radford, Lance [1] , Benny, Leslie [1] , Roth, Gregory [2] , Wright, Amy [3] , Chakrabarti, Debopam [*,1]
1. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA
2. Burnham Institute for Medical Research at Lake Nona, Orlando, FL, USA
3. Harbor Branch Oceanographic Intitute, Florida Atlantic University, Fort Pierce, FL, USA
NSR-RNA Seq identifies differentially regulated genes among P. falciparum isolates
Vignali, Marissa G. [1] , Chen, Jingyang [1] , Morrison, Robert [1] , Moon, Wonjong [1] , Fried, Michal [1] , Duffy, Patrick E. [*,1] , Armour, Christopher [2] , Castle, John [2] , Babak, Tomas [2] , Biery, Matthew [2] , Bouzek , Heather [2] , Raymond, Christopher [2]
1. SBRI, Seattle, WA, US
2. Rosetta Inpharmatics LLC, Seattle, WA, US
Nuclear proteomics to identify novel factors involved in nuclear function and gene expression in P. falciparum
Oehring, Sophie Clara [1] , Dietz, Olivier [1] , Pulfer, Andreas [1] , Flück, Christian [1] , Moes, Suzette [2] , Ralph, Stuart [3] , Jenö, Paul [2] , Voss, Till [*,1]
1. Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
2. Biozentrum, Basel, Switzerland
3. Biochemistry & Molecular Biology, Bio21 Molecular Science & Biotechnology Institute, Parkville, Australia
Nucleosome Landscape and Control of Transcription in the Human Malaria Parasite
Ponts, Nadia [*,1] , Harris, Elena Y [2] , Prudhomme, Jacques [1] , Hicks, Glenn [3] , Hardiman, Gary [4] , Lonardi, Stefano [2] , Le Roch, Karine G [1]
1. Department of Cell Biology and Neuroscience, UC Riverside, Riverside, CA, USA
2. Department of Computer Science and Engineering, UC Riverside, Riverside, USA
3. Institute of Integrative Genomics Biology, UC Riverside, Riverside, USA
4. Department of Medicine, UC San Diego, San Diego, USA
O
Organellar genomes of Chromera velia, the closest known relative to apicomplexan parasites
Oborník, Miroslav [*] , Janouškovec, Jan , Lai, De Hua , Keeling, Patrick , Lukeš, Julius
Molecular Biology, University of South Bohemia, Faculty of Science, Ceské Budejovice, Czech Republic
P
p24 receptors in the malaria parasite
Herrmann, Susann , Ruch, Ulrike , Spielmann, Tobias , Gilberger, Tim W. [*]
Bernhard- Nocht Institute for Tropical Medicine, Hamburg, Germany
Parachute drug discovery for neglected disease: Benchmark screening of human phosphodiesterase inhibitors against TbrPDEB1 and B2
Pollastri, Michael P [*,1] , Ashton, Trent D. [2] , Wang, Cuihua [1] , Gustafson, Alden [3] , Campbell, Robert K [3]
1. Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA
2. Department of Chemistry, Boston University, Boston, MA, USA
3. Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA
Parasites Hijack Host Calpain to Egress from Host Cells
Chandramohanadas, Rajesh [1] , Paul, Davis [2] , Beiting, Dan [2] , Michael, Harbut [1] , Millholland, Melanie [1] , Darling, Claire [1] , Velmourougane, Geetha [1] , Greer, Peter [3] , Roos, David [2] , Greenbaum, Doron [*,1]
1. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
2. Biology, University of Pennsylvania, Philadelphia, PA, USA
3. Queen’s University, Kingston, Canada
PfCRT - Balancing Drug Resistance and Fitness
Petersen, Ines , Palatulan, Eugene , Valderramos, Juan Carlos, Fidock, David [*]
Microbiology, Columbia University, New York, NY, USA
Pfmrk regulates progression through the S phase of the plasmodial cell cycle
Waters, Norman C. [*,1] , Jirage, Dayadevi [2] , Caridha, Diana P. [2] , Zhang, Veronica [1] , Gresty, Karryn [1] , Rowcliffe, Kerryn [1] , Chavchich, Marina [1]
1. Australian Army Malaria Institute, Enoggera, Australia
2. Walter Reed Army Institute of Research, Silver Spring, MD, USA
PfSUB1 and its role in Plasmodium falciparum egress
Silmon de Monerri, Natalie Claire, Blackman, Michael J [*]
Parasitology, National Institute for Medical Research, London, UK
Phenotypical and genotypical analysis of different mouse strains identifies new P. berghei ANKA malaria survival loci
Bopp, Selina [*,1] , Ramachandran, Vandana [2] , Ananthnaraya, Suchitra [3] , Gonzales, Gonzalo [1] , Watson, James [3] , Waters, Andy R [4] , Whiltshire, Tim [5] , Zhou, Yingyao [3] , Winzeler, Elizabeth [1]
1. Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
2. A*STAR, Singapore, Singapore
3. The Genomics Institute of the Novartis Foundation, La Jolla, CA, USA
4. University of Glasgow, Glasgow, Scotland
5. UNC School of pharmacy, Chapel Hill, NC, USA
Phylogenetic analysis and distribution of the plant-like ApiAP2 family of transcription factors in the Alveolates
Oberstaller, Jenna L [*] , Kissinger, Jessica C.
Genetics, University of Georgia, Athens, GA, USA
Placental trophoblast response to Plasmodium infected erythrocytes
Bailis, Anya Jeannine [*,1] , Tripathi, Abhai [2] , Sullivan, David [2]
1. Johns Hopkins Hospital, Baltimore, MD, USA
2. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Plasmepsin V is a PEXELase that directs malarial virulence proteins to the host cell
Boddey, Justin A [1] , Hodder, Anthony N [1] , Gunther, Svenja [1] , Gilson, Paul R [2] , Simpson, Richard J [3] , Pearce, J Andrew [1] , Crabb, Brendan S [2] , Cowman, Alan F [*,1]
1. Infection and Immunity, The Walter and Eliza Hall Institute for Medical Research, Parkville, Australia
2. Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
3. Ludwig Institute for Cancer Research and The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia
Plasmepsin V processes Plasmodium proteins destined for export into the host red blood cell
Russo, Ilaria , Babbitt, Shalon , Oksman, Anna , Goldberg, Daniel E [*]
Medicine/ Molecular Microbiology, Washington University/HHMI, St Louis, MO, USA
Plasmodium HMGB proteins: implication in the onset of cerebral malaria
Lawson-Hogban, Nadou , Briquet, Sylvie , Vaquero, Catherine [*]
INSERM UMRS 945, Paris, France
Polo-like kinase is required for trans-localization of the chromosomal passenger complex in regulating cytokinesis in Trypanosoma brucei
Li, Zhi , Umeyama, Takashi , Wang, Ching C. [*]
Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA
Polymorphism of Pseudouridine Synthase 1 reveals function in Toxoplasma gondii differentiation
Anderson, Matthew Zack [*] , Kriner, Michelle , Boothroyd, John C
Microbiology and Immunology, Stanford University, Stanford, CA, USA
Profiling the transcriptional landscape in Trypanosoma brucei by mRNA deep sequencing
Kolev, Nikolay G [*,1] , Franklin, Joseph B [2] , Ullu, Elisabetta [3] , Tschudi, Christian [1]
1. Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT, USA
2. Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA
3. Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, CT, USA
Protein export marks the early phases of gametocytogenesis of the human malaria parasite Plasmodium falciparum
Silvestrini, Francesco [1] , Olivieri, Anna [1] , Camarda, Grazia [1] , van Schaijk, Ben [2] , Sanchez, Massimo [1] , Younis Younis, Sumera [1] , Sauerwein, Robert [2] , Lasonder, Edwin [2] , Alano, Pietro [*,1]
1. Istituto Superiore di Sanitŕ, Rome, Italy
2. Radboud University Nijmegen , Nijmegen , The Netherlands
R
Receptor-ligand interactions for malaria parasite invasion of liver Kupffer cells
Cha, Sung-Jae [1] , Stins, Monique [2] , Jacobs-Lorena, Marcelo [*,1]
1. Molecular Microbiology & Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD, USA
2. Neuroscience, Johns Hopkins Medical Institute, Baltimore, MD, USA
Regulation and function of TgPL1, a patatin-like protein involved in T. gondii virulence and survival in activated macrophages
Tobin, Crystal M, Knoll, Laura J [*]
Medical Microbiology and Immunology, UW-Madison, Madison, WI, USA
Release of TRAP from the Sporozoite Surface is Required for Gliding Motility and Invasion of Target Organs
Ejigiri, Ijeoma , Kwakye, Kwadwo , Coppi, Alida , Bennett, Brandy , Sinnis, Photini [*]
Department of Medical Parasitology, New York University School of Medicine, New York, NY, USA
Relevance of the isoprenoid pathway in Toxoplasma gondii
Li, Zhu-Hong [1] , Behera, Ranjan [1] , Moreno, Silvia [*,2]
1. Dept. of Cell Biology, The Univesity of Georgia, Athens, GA, USA
2. Dept. of Cell Biology, The university of Georgia, Athens, GA, USA
Repurposing human drug discovery: Development of human gene family-based screening sets for parasitology research
Pollastri, Michael P [*,1] , Campbell, Rob K [2] , Ruben, Larry [3] , Wang, Ching Chung [4] , Beverley, Stephen M. [5] , Navarro, Miguel [6]
1. Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA
2. Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA
3. Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA
4. Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, CA, USA
5. Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA
6. Instituto de Parasitología y Biomedicina, Granada, Spain
Requirement for ISCL in Leishmania infection: An Essential Role of Host Sphingolipid Degradation in Virulence?
Zhang, Ou [1] , Wilson, Mattie [1] , Key, Philip [2] , Hsu, Fong-fu [3] , Turk, John [3] , Kuhlmann, Matthew [3] , Beverley, Stephen M [2] , Zhang, Kai [*,1]
1. Biological Sciences, Texas Tech University, Lubbock , TX, USA
2. Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA
3. Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Reverse genetic analysis of erythrocyte determinants of P. falciparum invasion and growth
Bei, Amy Kristine, Dvorin, Jeff D, Duraisingh, Manoj T [*]
Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model prediction
Pizzi, Elisabetta [*,1] , Bultrini, Emanuele [1] , Brick, Kevin [1] , Mukherjee, Srayanta [2] , Zhang, Yang [2] , Silvestrini, Francesco [1] , Alano, Pietro [1]
1. Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
2. Department of Molecular Biosciences Center for Bioinformatics , University of Kansas, Lawrence, KS, USA
Rhomboid 4 is Essential for Toxoplasma gondii Host Cell Invasion
Buguliskis, Jeff S. [*,1] , Brossier, Fabien [2] , Sibley, L. David [*,1]
1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA
2. ‡Institut National de la Receherche Agronomique, Tours, France
Role of Mitochondrial Dehydrogenases in Blood stage Malaria Parasites
Maddur Ganesan, Suresh [1] , Morrisey, Joanne M. [1] , Painter, Heather J. [2] , Mather , Michael W. [1] , Vaidya, Akhil B. [*,1]
1. Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA, USA
2. Molecular Biology, Princeton University, Princeton, NJ, USA
ROLE OF TOXOPLASMA METHYLCITRATE CYCLE IN MOBILIZATION OF HOST AMINO ACIDS AS CARBON SOURCE
Limenitakis, Julien [1] , Fleige, Tobias [1] , Riezman, Howard [2] , Soldati, Dominique [*,1]
1. Departement of microbiology and molecular medicine, University of Geneva, Geneva, Switzerland
2. Departement of Biochemistry, University of Geneva, Geneva, Geneva
Role of Trypanosoma cruzi PI-PLC in host-parasite interaction
Martins, Vicente de Paulo [1] , Maric, Danijela [2] , Engman, David M [2] , Docampo, Roberto [1] , Moreno, Silvia NJ [*,1]
1. Cellular Biology, University of Georgia, Athens, GA, USA
2. Department of Pathology, Northwestern University, Chicago, IL, USA
S
Scanning the Plasmodium falciparum Genome for Signals of Natural Selection and Genome-Wide Associations
Wirth, Dyann Fergus [1] , Cooke, Sarah Volkman [*,1] , Neafsey, Dan [2] , Angelino, Elaine [3] , Schaffner, Stephen F. [4] , Park, Danny [2] , Cortese, Joe [3] , Barnes, Kayla [1] , Daniels, Rachel [3] , Rosen, David [1] , Van Tyne, Daria [1] , Johnson, Charles [3] , Sarr, Ousmane [5] , Mboup, Souleymane [5] , Milner, Danny A. [1] , Galagan, James E. [6] , Wiegand, Roger C. [3] , Hartl, Daniel L. [7] , Birren, Bruce [2] , Lander, Eric [8] , Wirth, Dyann Fergus [1] , Sabeti, Pardis C. [7]
1. Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
2. Genome Sequencing & Analysis Program, Broad Institute/MIT, Cambridge, MA, USA
3. Infectious Disease Initiative, Broad Institute/MIT, Cambridge, MA, USA
4. Center for Genome Research, Broad Institute/MIT, Cambridge, MA, USA
5. Laboratoire de Bacteriologie Virologie, Universite Cheikh Anta Diop, Dakar, Senegal
6. Microbial Genome Analysis and Annotation, Broad Institute/MIT, Cambridge, MA, USA
7. Organismal and Evolutionary Biology, Harvard University, Cambridge, MA, USA
8. Center for Genome Research, Broad Institute/MIT, Cambridge, MA, USA
Screening for CD8+ T cell epitopes of T. gondii protein restricted by the HLA-A02, -A03 or -B07 supertype
Cong, Hua , Tan, Tze Guan, Mui, Ernest J, McLeod, Rima [*]
Ophthalmology and Visual Sciences, University of Chicago, Chicago, IL, USA
Similarities between the proteophosphoglycan of Entamoeba histolytica and bacterial dextran
carpentieri, andrea
Dept. of Molecular and Cell Biology, Boston University Medical Campus, boston, MA, USA
Single-plasmid dual luciferase assay allows detailed study of Plasmodium promoter activity and characterization of a novel liver stage-specific promoter
Helm, Susanne [*] , Lehmann, Christine , Nagel, Andreas , Stanway, Rebecca R, Heussler, Volker T
Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
Small Molecule Mimics of Antimicrobial Peptides as Antimalarials
Berdougo, Eli [1] , Millholand, Melanie [1] , Harbut, Michael [1] , Shanmugan, Dhanasekaran [2] , Jo, Hyunil [3] , Lucumi, Edinson [4] , Scott, Richard [5] , Diamond, Scott [4] , Degrado, William [3] , Greenbaum, Doron [*,1]
1. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
2. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
3. Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, USA
4. Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA
5. Polymedix Pharmaceuticals, Radnor, PA, USA
Streamlined architecture and GPI-dependent trafficking in the early secretory pathway of African trypanosomes
Sevova, Elitza , Bangs, James D. [*]
Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA
Striated Fiber Assemblins in Toxoplasma gondii
Jordan, Carly N [*,1] , Patel, Jay [1] , White, Michael [2] , Striepen, Boris [1]
1. Cellular Biology, University of Georgia, Athens, GA, USA
2. Molecular Medicine, University of South Florida, Tampa, FL, USA
Structural and functional studies of the varO variant of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1)
Juillerat, Alexandre [*,1] , Lewit-Bentley, Anita [1] , Vigan-Womas, Ines [2] , Guillotte, Micheline [2] , Gangnard, Stephane [1] , Faure, Grazyna [1] , Igonet, Sebastien [1] , Mercereau-Puijalon, Odile [2] , Bentley, Graham [1]
1. Department of Structural Biology and Chemistry, Institut Pasteur, Paris, France
2. Parasitology and Mycology, Institut Pasteur, Paris, France
Structural basis of Anopheles gambiae thioester-containing protein 1 killing of Plasmodium
Baxter, Richard H. G. [*,1] , Chelliah, Yogarany [1] , Fraiture, Malou [2] , Steinert, Stefanie [2] , Levashina, Elena A [2] , Deisenhofer, Johann [1]
1. Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA
2. UPR9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
Deng, Xiaoyi [1] , Gujjar, Ramesh [2] , Mazouni, FarahMazouni1 El [1] , Kaminsky, Werner [2] , Malmquist, Nicholas [1] , Goldsmith, Elizabeth J. [3] , Rathod, Pradipsinh K. [*,2] , Phillips, Margaret [*,1]
1. Pharmacology, UT Southwestern Medical Center, Dallas, TX, U.S.
2. University of Washington, Seattle, WA, U.S.
3. UT Southwestern Medical Center, Dallas, TX, U.S.
Structure determination of the Toxoplasma gondii Macrophage Migration Inhibitory Factor homologue (TgMIF) defines biochemical functional properties
Henriquez, Fiona Luisa [*,1] , Sommerville, Caroline [2] , Williams, Roderick A.M [2] , Richardson, Julia [3] , Mottram, Jeremy C [4] , Roberts, Craig W [2] , Alexander, James [2]
1. School of Science, University of the West of Scotland, Paisley, UK
2. SIPBS, University of Strathclyde, Glasgow, UK
3. Structural Biology, University of Edinburgh, Edinburgh, UK
4. Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Structure function analysis of a prototypical ApiAP2 transcriptional regulator from P. falciparum
Lindner, Scott E [*,1] , De Silva, Erandi [2] , Keck, James L. [1] , Llinas, Manuel [2]
1. Dept of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, USA
2. Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
Subcellular localization of P. falciparum gametocyte development gene, Pfgdv1
Eksi, Saliha [1] , Haile, Yoseph [1] , Morahan, Belinda J [1] , Furuya, Tetsuya [2] , Suri, Amreena [1] , Jiang, Hongying [2] , Su, Xinzhuan [2] , Williamson, Kim C [*,1]
1. Biology, Loyola University Chicago, Chicago, IL, USA
2. NIH, Bethesda, MD, USA
Suggestive evidence for Darwinian selection against asparagine-linked glycans of Plasmodium and Toxoplasma
Bushkin, G. Guy [*,1] , Ratner, Daniel M. [2] , Duraisingh, Manoj T [3] , Dvorin, Jeffrey D. [3] , Gubbels, Marc-Jan [4] , Robbins, Phillips W. [1] , Samuelson, John [1]
1. Molecular and Cell Biology, Boston University, Boston, MA, USA
2. Bioengineering, University of Washington, Seattle, WA, USA
3. Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
4. Biology, Boston College, Boston, MA, USA
Surface-Localized Sugar Permeases and Host-Derived Glucose are Dispensable for the Obligate Intracellular Parasite Toxoplasma gondii
Blume, Martin [*,1] , Rodriguez-Contreras, Dayana [2] , Landfear, Scott [2] , Fleige, Tobias [3] , Soldati, Dominique [3] , Lucius, Richard [1] , Gupta, Nishith [*,1]
1. Dept. of Molecular Parasotology, Humboldt University, Berlin, Germany
2. Oregon Health and Sciences University, Portland, OR, USA
3. University of Geneva, Geneva, Switzerland
T
Target Gene Duplication in ARMD Plasmodium falciparum Acquiring Drug Resistance
Freeman, Dan L [1] , Ponmee, Napawan [1] , White, John [1] , Guler, Jennifer L [1] , Gujjar, Ramesh [1] , Marwaha, Alka [1] , Phillips, Margaret A [2] , Rathod, Pradipsinh K [*,1]
1. Chemistry, University of Washington, Seattle, WA, USA
2. Pharmacology, University of Texas Southwestern Medical Center , Dallas, TX, USA
Targeting Entamoeba histolytica Asparagine-Linked Glycans
Ratner, Daniel [*,1] , Sheih, Alyssa [1] , Ghosh, Sudip K [2] , OKeefe, Barry [3] , Lubrano, Michael [2] , Robbins, Phillips [2] , Samuelson, John [2]
1. University of Washington, SeaTac, WA, U.S.A.
2. Boston University, School of Dental Medicine, Boston, MA, U.S.A.
3. National Cancer Institute, Frederick, MD, U.S.A.
Telomeric DNA modification and the regulation of T.cruzi virulence
Ekanayake, Dilrukshi K [1] , Minning, Todd [2] , Tarleton, Rick [2] , Sabatini, Robert [*,1]
1. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States
2. Center of Emerging Global Infectious Diseases , University of Georgia, Athens, GA, United States
The antimalarial effects of the small molecule fosmidomycin are mediated exclusively through blockade in isoprenoid biosynthesis
Hodge, Dana M [1] , Feng, Jutao [1] , Zhang, Baichen [2] , Hicks, Leslie [2] , Odom, Audrey R [*,1]
1. Pediatrics, Washington University School of Medicine, St Louis, MO, USA
2. Proteomics and Mass Spectrometry Facility, Danforth Plant Sciences Center, St Louis, MO, usa
The apicoplast ferredoxin redox system as the electron donor
for malaria iron-sulfur-proteins
Bosch, Gundula [1] , Gisselberg, Jolyn E. [2] , Prigge, Sean T. [*,1]
1. Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Baltimore, MD, USA
2. Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
The application of the bxb1 intergrase system to explore gene regulation in Plasmodium falciparum
Wong, Eleanor HM [*] , Horrocks, Paul
Institute of Science and Technology in Medicine, Keele University, Staffordshire, United Kingdom
The bilobe structure of Trypanosoma brucei contains a MORN-repeat protein
Morriswoood, Brooke [1] , He, Cynthia [2] , Sealey-Cardona, Marco [1] , Yelinek, Jordan [3] , Pypaert, Marc [3] , Warren, Graham [*,1]
1. Max F. Perutz Laboratories, Vienna, Austria
2. National University of Singapore, Singapore, Singapore
3. Yale University School of Medicine, New Haven, CT, USA
The Chromatin Landscape of Plasmodium falciparum
Ying, Zhu Irene [*,1] , Yassour, Moran [2] , Garcia, Benjamin A [3] , Regev, Aviv [4] , Llinás, Manuel [1]
1. Molecular Biology and Integrative Genomics, Princeton University, Princeton, NJ, USA
2. Computational Biology, The Hebrew University of Jerusalem/The Broad Institute of MIT and Harvard, Jerusalem, Israel
3. Molecular Biology, Princeton University, Princeton, NJ, USA
4. The Broad Institute of MIT and Harvard, Cambridge, MA, USA
The cohesin complex regulates epigenetic inheritance of VSG expression in Trypanosoma brucei
Bart, Jean-Mathieu , Landeira, David , Van Tyne, Daria , Navarro, Miguel [*]
Molecular biology, Institute Parasitology and Biomedicine, Armilla, Spain
The conserved region of the Plasmodium falciparum stevor multigene family binds to erythrocytes and potentially inhibits in vitro merozoite invasion
Niang, Makhtar , Pelly, Shaaretha , Yeo, Kim Pin, Preiser, Peter R [*]
School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
The control of nuclear localization of Myb1 by Protein phosphatase 1 in Trichomonas vaginalis
Chu, Chien-Hsin , Tai, Jung-Hsiang [*]
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
The Elusive Mitochondrial Genome of Toxoplasma gondii
xiao, wenyuan , Hall, Erica M, Kissinger, Jessica C [*]
Department of Genetics, University of Georgia, Athens, GA, U.S.
The Engines of the relict Plastid of Malaria Parasites
Lim, Liting [1] , Weber, Andreas P [2] , Linka, Marc [2] , Mullin, Kylie A [1] , McFadden, Geoffrey I [1]
1. School of Botany, University of Melbourne, Melbourne, Victoria, Australia
2. Institute of Plant Biochemistry, Heinrich-Heine University, Duesseldorf, Germany
The Function of a MYST Family Histone Acetyltransferase in the Malaria Parasite Plasmodium falciparum
Miao, Jun , Cui, Long , Fan, Qi , Li, Xiaolian , Cui, Liwang [*]
Department of Entomology, Pennsylvania State University, University Park, PA, USA
The interactome of thioredoxin-related proteins in malarial parasites
Jortzik, Esther , Sturm, Nicole , Mailu, Boniface , Koncarevic, Sasa , Rahlfs, Stefan , Becker, Katja [*]
Interdisciplinary Research Center, Justus-Liebig University Giessen, Giessen, Germany
The Leu-rich repeats of the cyst wall protein 1 (CWP1) of Giardia lamblia form a lectin domain that binds fibrils of the GalNAc homopolymer.
Chatterjee, Aparajita [1] , Carpentieri, Andrea [1] , Ratner, Daniel M [1] , Bullit, Esther [2] , Robbins, Phillips W [1] , Samuelson, John C [*,1]
1. Molecular and Cell Biology, Boston University, Goldman School of Dental Medicine, Boston, USA
2. Department of Biophysics and Physiology, Boston University,School of Medicine, Boston, MA, USA
The Plasmodium falciparum kahrp promoter revisited
Witmer, Kathrin , Brancucci, Nicolas , Flueck, Christian , Voss, Till [*]
Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
The Plasmodium protease ROM1 is important for early development of parasites within hepatocytes shortly after sporozoite invasion
Vera, Iset Medina [1] , Beatty, Wandy [2] , Sinnis, Photini [3] , Kim, Kami [*,1]
1. Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States
2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA
3. Department of Medical Parasitology, New York University School of Medicine, New York, NY, USA
The RNA-binding protein RBP10 controls energy metabolism in bloodstream-form Trypanosoma brucei
Wurst, Martin , Queiroz, Rafael , Clayton, Christine [*]
ZMBH, Heidelberg, Germany
The role of Plasmodium cGMP dependent protein kinase in liver stage development
Bhanot, Purnima [*,1] , Falae, Adebola [1] , Amaladoss, Anburaj [1] , Combe, Audrey [2] , Carvalho, Teresa Gil [2] , Menard, Robert [2]
1. Microbiology and Molecular Genetics, UMDNJ - New Jersey Medical School, Newark, NJ, USA
2. Unite de Biologie et Genetique du Paludisme, Institut Pasteur, Paris, France
The role of trypanosome-specific proteins P34 and P37 in ribosomal biogenesis
Wang, Lei , Williams, Noreen [*]
Microbiology & Immunobiology, University at Buffalo, Buffalo, NY, United States
The RSC8 locus of Toxoplasma gondii affects expression of select bradyzoite markers
Rooney, Peggy J [*,1] , Craver, Mary Patricia J [2] , Knoll, Laura J [1]
1. Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, USA
2. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
The Toxoplasma gondii basal complex is a multilayered structure facilitating an essential constrictive role in cell division
Anderson-White, Brooke R. [1] , Lorestani, Alexander [1] , Ivey, F. Douglas [1] , Brooks, Carrie [2] , Striepen, Boris [2] , Beckers, Con [3] , Ferguson, David J.P. [4] , Cheng, Katherine [1] , Robertson, Seth D. [1] , Yang, Kevin [1] , Sahoo, Nivedita [1] , Gubbels, Marc-Jan [*,1]
1. Department of Biology, Boston College, Chestnut Hill, MA, USA
2. Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA
3. Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
4. Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, UK
The Toxoplasma gondii parasitophorous vacuole membrane contains both expected and surprising activities.
Martin, Angela M [1] , Liu, Ting [2] , Ghosh, Debasish [1] , Walton, Julia [1] , Lynn, Bert C [2] , Sinai, Anthony P [*,1]
1. Microbio. Immuno. and Molec. Genet., University of Kentucky College of Medicine, Lexington, KY, USA
2. Chemistry, University of Kentucky , Lexington, KY, USA
The Toxoplasma moving junction components form a novel invasion machine
Straub, Kurtis W., Cheng, Stephen J., Sohn, Catherine S., Bradley, Peter J. [*]
MIMG, University of California, Los Angeles, Los Angeles, CA, USA
The ubiquitin-proteasome system regulates metaphase-anaphase transition but not G1/S transition or mitotic exit in Trypanosoma brucei
Wang, C. C. [*] , Li, Ziyin
Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA
The Unusual ATP Synthase Complexes in Alveolate Protists
Balabaskaran Nina, Praveen [*,1] , Dudkina, Natalya [2] , Kane, Lesley A [3] , Morrisey, Joanne [1] , Ke, Hangjun [1] , van Eyk, Jennifer E [3] , Boekema, Egbert [2] , Mather, Michael W [1] , Vaidya, Akhil B [1]
1. Microbiology and Immunology, Drexel university college of medicine, philadelphia, united states of america
2. Department of Biophysical Chemistry, University of Groningen, Groningen, netherlands
3. Department of Biological Chemistry, The Johns Hopkins University, Baltimore, MD, USA
Toward the development of an AP2-based inducible expression system for Plasmodium species
Pino, Paco [1] , Sebastian, Sarah [2] , Bush, Erin [3] , Llinas, Manuel [3] , Billker, Oliver [2] , Soldati-Favre, Dominique [*,1]
1. Microbiology and Molecular Medicine, Universtiy of Geneva, Geneva, Switzerland
2. Wellcome Trust Sanger Institute, Hinxton Cambridge, ME, UK
3. Department of Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, USA
Toxoplasma gondii secreting Cre-recombinase- a potent tool for studying host-pathogen interactions
Koshy, Anita [*,1] , Fouts, Ashley [2] , Lodoen, Melissa B [2] , Poukchanski, Anya [2] , Alkan, Ozan [3] , Blau, Helen M. [3] , Boothroyd, John C [2]
1. Microbiology & Immunology/ Division of Infectious Disease, Stanford University, Stanford, CA, USA
2. Microbiology & Immunology, Stanford University, Stanford, CA, USA
3. Microbiology & Immunology, Stanford University, Stanford, CA, USA
Toxoplasma gondii selectively targets PHD2 to increase stabilization of the host cell transcription factor, hypoxia inducible factor 1
Wiley, Mandi , Blader, Ira [*]
Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Trafficking of mini-var GFP fusion proteins in Plasmodium falciparum infected erythrocytes
Melcher, Martin [*,1] , Muhle, Rebecca A. [2] , Kraemer, Susan M. [1] , Smith, Joseph D. [1] , Fidock, David A. [2]
1. Seattle Biomedical Research Institute, Seattle, WA, USA
2. Albert Einstein College of Medicine, Yehiva University, New York, NY, USA
Transcriptional Analysis of the Pre-erythrocytic Stages of Plasmodium
Williams, Calvin T, Azad, Abdu, PhD [*]
Molecular Microbiology and Immunology, University of Maryland School of Medicine, BALTIMORE, MD, USA
Transcriptional changes in Giardia lamblia during in vitro interactions with human cells
Ringqvist, Emma E [*] , Troell, Karin , Svärd, Staffan G
Dep of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden
Trifluorothymidine may be a Promising Drug for Cryptosporidiosis: Understanding the Mechanism of its Anti-parasitic Activity
Sun, Xin [1] , Sharling, Lisa [2] , Striepen, Boris [2] , Mead, Jan [3] , Martucci, Walter E [4] , Anderson, Karen S [4] , Hedstrom, Lizbeth [*,5]
1. Graduate Program in Biochemistry, Brandeis University, Waltham, United States
2. Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, United States
3. Atlanta VA Medical Center and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States
4. Department of Molecular Biophysics and Biochemistry and Department of Pharmacology, Yale University School of Medicine, New Haven, CT, United States
5. Department of Biology and Chemistry, Brandeis University, Waltham, MA, United States
tRNA Synthetases of Tri-Tryp Protozoa as Targets for Drug Development
Buckner, Frederick S [*,1] , Fan, Erkang [2] , Verlinde, Christophe [2] , Van Voorhis, Wesley [1] , Merritt, Ethan [2] , Hol, Wim [2]
1. Medicine, University of Washington, Seattle, USA
2. Biochemistry, University of Washington, Seattle, WA, USA
Turning enzymes ON with small molecules
Wells, Jim
Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA
Two distinct subunit 9 isoforms are incorporated into the Trypanosoma brucei ATP synthase complex
Gulde, Paul E., McManaman, Charity , Williams, Noreen [*]
Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA
U
Unusual promoter structure within the locus of active ves transcription of Babesia bovis
Huang, Yingling , Wang, Xinyi , Allred, David R [*]
Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA
Unusual RNAi pathway genes control generation of and effect by small RNAs in Entamoeba histolytica
Zhang, Hanbang , Ehrenkaufer, Gretchen , Singh, Upinder [*]
Internal Medicine and Microbiology and Immunology, Stanford University, Stanford, CA, USA
V
Var gene activation follows a strict hierarchy in Plasmodium falciparum
Enderes, Corinna [1] , Dzikowski, Ron [2] , Frank, Matthias [*,1]
1. Parasitology, Institute for Tropical Medicine, Tuebingen, Germany
2. Department of Parasitology, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Institute for Medical Resear, Jerusalem, Israel
Vesicular Trafficking In Apicomplexan Parasites
Klaus, Katrin [*,1] , Hertrich, Nadine [2] , Mahler, Sabine , Meissner, Markus
1. Department of Parasitology, University of Heidelberg Medical School, Heidelberg, Germany
2. University of Heidelberg Medical School, Heidelberg, Germany
W
Whole genomic allelic variation scanning of P. vivax using high-density microarrays reveals highly variable genes and population genetic structures
Westenberger, Scott J [*,1] , Dharia, Neekesh V [1] , Bacon, David J [2] , Vinetz, Joseph M [3] , Winzeler, Elizabeth A [1]
1. Cell Biology, The Scripps Research Institute, La Jolla, CA, United States
2. Navy Environmental and Preventative Medicine Unit-2, US Navy, Norfolk, VA, United States
3. School of Medicine, University of California, San Diego, San Diego, CA, United States
Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei
Parsons, Marilyn [*] , Jensen, Bryan C., Sivam, Dhileep , Kifer, Charles T., Myler, Peter J.
Seattle Biomedical Research Institute, Seattle, WA, USA
237 abstract(s) listed
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