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2007 Molecular Parasitology Meeting: Accepted Abstracts

2007 Molecular Parasitology

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	2007 Molecular Parasitology: Accepted Abstracts Abstracts are listed alphabetically by title; use the links below to jump to the desired section of the list. To search for a specific keyword or author, try using your browser's "Find" command. To see abstracts organized by session instead (including the time and day of each session) download the following PDF file: * = presenting author A B C D E F G H I J K L M N O P Q R S T U 3 *3’UTR elements of the Trypanosoma brucei* ATP synthase subunits mediate developmental gene expression** Brown, Silvia V, Velayo, Alma , Williams, Noreen [] Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA A A Chemical Rationale for Identification of Next Generation Quinoline Methanols as New Antimalarials* Lanteri, Charlotte A [,1] , Caridha, Diana [1] , Gerena, Lucia [1] , Gettayacamin, Montip [2] , McCalmont, William [3] , Heady, Tiffany [3] , Melendez, Victor [3] , Dow, Geoffrey S [1] 1. Parasitology, Walter Reed Army Institute of Research, Silver Spring, MD, USA 2. Department of Veterinary Medicine, Armed Forces Institute of Research, Bangkok, Thailand 3. Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Silver Spring, MD, USA A component in the serum substitute Albumax II greatly alters the sensitivity of Plasmodium falciparum* to pantothenamides** Spry, Christina [,1] , Virga, Kristopher G [2] , Lee, Richard E [3] , Saliba, Kevin J [1] 1. School of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT, Australia 2. Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Centre, Kingsville, TX, USA 3. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA A Conserved Basic Groove on Aldolase Mediates MIC2 Cytoplasmic Tail and F-Actin Binding* Starnes, G. Lucas [1] , St-Jean, Miguel [2] , Sygusch, Jurgen [2] , Sibley, L. David [,1] 1. Molecular Microbiology & MIcrobial Pathogenesis, Washington University in St. Louis, St. Louis, MO, United States 2. Department of Biochmistry, University of Montreal, Montreal, Canada A A diverse and complex repertoire of small RNAs control gene expression and developmentally regulated genes in Entamoeba histolytica* Singh, Upi [] , Zhang, Hanbang Internal Medicine and Microbiology and Immunology, Stanford University, Stanford, CA, USA A functional screen to identify the role for exported proteins in the Plasmodium falciparum-infected erythrocyte* Maier, Alexander G. [,1] , Rug, Melanie [2] , O Neill, Matthew T. [1] , Brown, Monica [1] , Chakravorty, Srabasti J. [3] , Szestak, Tadge [3] , Chesson, Joanne [2] , Wu, Yang [3] , Hughes, Katie [3] , Coppel, Ross [4] , Newbold, Chris [5] , Beeson, James [2] , Craig, Alister [3] , Crabb, Brendan S. [2] , Cowman, Alan F. [2] 1. The Walter and Eliza Hall Institute of Medical Research, Bundoora, Australia 2. The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia 3. Liverpool School of Tropical Medicine, Liverpool, United Kingdom 4. Monash University, Clayton, Australia 5. Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom A genome sequence survey of the gregarine, Ascogregarina taiwanensis, and comparative analysis with Cryptosporidium and other apicomplexans* Templeton, Thomas J. [1] , Enomoto, Shinichiro [2] , Abrahamsen, Mitchell S. [2] , Chen, Wei-June [3] , Zhu, Guan [,4] 1. Microbiology and Immunology, Weill Cornell Medical College, New York, NY, NY, USA 2. Department of Veterinary Pathobiology, University of Minnesota, St Paul, MN, USA 3. Department of Public Health and Parasitology, Colled of Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan 4. Department of Veterinary Pathobiology, College of Veterinary Medicine Texas A&M University, College Station, TX, USA A genome-wide scan for chromosomal regions involved in antimalarial resistance* Nair, Shalini [,1] , Sudimack, Dan [1] , Williams, Jeff T [1] , Goring, Harald [1] , Barends, Marion [2] , Jaidee, Anchalee [2] , Nosten, Francois [2] , Anderson, Tim [1] 1. Southwest Foundation for Biomedical Research, San Antonio, TX, USA 2. Shoklo Malaria Research Unit, Mae Sot, Thailand A Homolog of pfcrt* Modulates Chloroquine Accumulation in Dictyostelium discoideum** Sa, Juliana Martha [1] , Brzostowski, Joseph A [2] , Wellems, Thomas E [,1] 1. Laboratory of Malaria and Vector Research, NIAID, Rockville, MD, USA 2. NIAID, Rockville, MD, USA A Large Non-Coding RNA regulates processing of the insect form of rRNA in Plasmodium falciparum* Sharma, Indu [1] , Fang, Jun [2] , McCutchan, Thomas F [,1] 1. LMVR, NIAID, NIH, Rockville, MD, USA 2. Advanced Technology Center, NCI,NIH, Gaithersburg, MD, USA A model for severe anemia in malaria: non-parasitized erythrocytes with Plasmodium falciparum* ring surface protein 2 show reduced deformability in microfluidic channels** Antia, Meher [,1] , Delaby, Amélie [2] , Herricks, Thurston [1] , Dechavanne, Sébastien [2] , Rathod, Pradipsinh [1] , Gysin, Jürg [2] , Scherf, Artur [3] 1. Chemistry, University of Washington, Seattle, USA 2. Parasitologie Expérimentale, Université de la Méditerranée, Marseille, France 3. Biologie des interactions hôte-parasite, Institut Pasteur, Paris, France A multifunctional serine protease in the malarial parasitophorous vacuole* Koussis, Konstantinos [1] , Yeoh, Sharon [1] , O’Donnell, Rebecca A. [1] , Hackett, Fiona [1] , Withers-Martinez, Chrislaine [1] , Juliano, Luiz [2] , Blackman, Michael J. [,1] 1. Division of Parasitology, The National Institute for Medical Research, London, United Kingdom 2. Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil A network of protein export in erythrocytes infected with the malaria parasite* Bhattacharjee, Souvik [1] , van Ooij, Christiaan [1] , Balu, Bharath [2] , Adams, John H. [2] , Haldar, Kasturi [,1] 1. Pathology and Microbiology-Immunology, Northwestern University, Chicago, IL, USA 2. Global Health Infectious Diseases Research (GHIDR) Program, College of Public Health, University of South Florida, Tampa, FL, USA A New Azido – Chloroquine Probe that Efficiently Photolabels Purified PfCRT* Natarajan, Jayakumar [1] , Lekostaj, Jacqueline [1] , Amoah, linda [1] , Paguio, Michelle [1] , Wolf, Christian [2] , Roepe, Paul [,1] 1. Biochemistry, Cell. & Mol. Biol., Georgetown University, washington , DC, USA 2. chemistry, Georgetown University, Washington, DC, USA A New Fluorescent Chloroquine Probe For Investigating the Mechanism of Chloroquine Resistance* Cabrera, Mynthia [1] , Paguio, Michelle [1] , Natarajan, Jayakumar [1] , Wolf, Christian [2] , Roepe, Paul [,1] 1. Biochemistry, Cell. & Mol. Biol., Georgetown University, washington, DC, USA 2. Chemistry, Georgetown University, Washington , DC, USA A Plasmodium-specific gene, PF GYI1, is required for the induction of gametocytogenesis* Eksi, Saliha [1] , Haile, Yoseph [1] , Furuya, Tetsuya [2] , Suri, Amreena [1] , Su, Xinzhuan [2] , Williamson, Kim C [,1] 1. Loyola University Chicago, Chicago, IL, USA 2. NIAID, NIH, Bethesda, MD, USA A Potential Role for gp34, a GPI-anchored Theileria* surface protein, in the synchronization of parasite and host cell division** Xue, Gongda [1] , Peyer, Martina [1] , von Schubert, Conrad [,1] , Hermann, Pascal [1] , Buetikofer, Peter [2] , Hehl, Adrian [3] , Dobbelaere, Dirk A. [1] 1. Vetsuisse Faculty, University of Bern, Bern, Switzerland 2. University of Bern, Bern, Switzerland 3. University of Bern, Bern, Switzerland A proteomic view of the Malarial rupture From the HOST RBC* Chandramohanadas, Rajesh [1] , Wehr, Angela [2] , Greenbaum, Doron [,1] 1. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA 2. Pharmacology, University of pennsylvania, Philadelphia, PA, USA A Public Plasmodium Genome Browser using UCSC Browser Software* Chakrabarti, Kausik [1] , Deans, Jonathan [2] , Sterne-Weiler , Timothy [2] , Donohue , John Paul [3] , Ares, Manuel [,3] 1. Molecular Cell and Develoomental Biology, University of California Santa Cruz, Santa Cruz, CA, USA 2. Hughes Undergraduate Research Laboratory (HURL), University of California Santa Cruz, Santa Cruz, CA, USA 3. University of California Santa Cruz, Santa Cruz, CA, USA A Real-time Quantitative PCR-based Assay for Enhanced Detection of Hematodinium sp. Infection and Tissue Invasion in the Blue Crab (Callinectes sapidus)* Williams, Kimberly D [1] , Nagle, Lara [2] , Place, Al R [3] , Schott, Eric J [4] , Hanif, Ammar [5] , Jagus, Rosemary [3] , Messick, Gretchen [6] , Pitula, Joseph [] 1. Natural Sciences, University of Maryland Eastern Shore, Princess Anne, MD, USA 2. University of Maryland Eastern Shore, Princess Anne, MD, USA 3. Center of Marine Biotechnology, Baltimore, MD, USA 4. Center of Marine Biotechnology; Oxford Cooperative Laboratory, Baltimore, MD, USA 5. Morgan State University, Baltimore, MD, USA 6. Oxford Cooperative Laboratory, Oxford, MD, USA A recombineering system for genetic manipulation in Toxoplasma gondii* van Dooren, Giel , Brooks, Carrie F, Muthalagi, Mani , Reiff, Sarah , Jordan, Carly N, Nair, Sethu , Striepen, Boris [] Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, U.S.A. A role for telomeric DNA glycosylation in the regulation of antigenic variation in T.brucei* Cliffe, Laura , Kieft, Rudo , Sweeney, Kate , Birkeland, Shanda , Southern, Robbie , Sabatini, Robert [] University of Georgia, Athens, GA, USA A tale of two GCN5s: an unusual pair of histone acetyltransferases in the protozoan parasite Toxoplasma gondii* Dixon, Stacy E [] , Livingston, Meredith R, Bhatti, Micah M, Sullivan, Jr., William J Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA A Toxoplasma gondii* homologue of Tic20 (TgTic20) is essential for apicoplast protein import, apicoplast biogenesis and parasite survival** van Dooren, Giel [,1] , Tomova, Cveta [2] , Agrawal, Swati [3] , Humbel, Bruno [2] , Striepen, Boris [1] 1. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA 2. Department of Biology, Utrecht University, Utrecht, The Netherlands 3. Department of Cellular Biology, University of Georgia, Athens, GA, USA A transmembrane form of the Plasmodium falciparum* MAEBL is essential for the invasion of Anopheles salivary glands** Saenz, Fabian [,1] , Balu, Bharath [1] , Smith, Jonah [2] , Adams, John H [1] 1. Global Health, University of South Florida, Tampa, FL, USA 2. Biological Sciences, University of Notre Dame, Notre Dame, IN, USA A universal SNP-based molecular barcode for P. falciparum identification and tracking* Daniels, Rachel [1] , Volkman, S. [2] , Milner, D. [2] , Park, D. [1] , Wirth, D.F. [2] , Wiegand, R.C. [,1] 1. Broad Institute of MIT and Harvard, Cambridge, USA 2. Harvard School of Public Health, Boston, MA, USA A var* specific nuclear factor is involved in transcriptional activation of virulence genes in the malaria parasite Plasmodium falciparum** Dzikowski, Ron [] , Deitsch, Kirk W Microbiology and Immunology, Weill Medical College, Cornell University, New York, NY, USA A variant protein linked to nutrient and lipid import is required for blood stage infection by human malaria* Tamez, Pamela [1] , vanOoij, Christiaan [1] , Hiller, Natalia Luisa [1] , Bhattacharjee, Souvik [1] , Balu, Bharath [2] , Adams, John H. [2] , Haldar, Kasturi [,1] 1. Pathology and Microbiology-Immunology, Northwestern University, Chicago, IL, USA 2. Global Health Infectious Diseases Research (GHIDR) Program, College of Public Health, University of South Florida,, Tampa, FL, USA Adaptive copy number evolution in a key gene in the folate pathway of malaria parasites* Anderson, Tim JC [,1] , Nair, Shalini [2] , Patel, Jigar [3] , Blain, J Craig [4] , Miller, Becky [3] , Barends, Marion [5] , Jaidee, Anchalee [5] , Mayxay, Mayfong [6] , Newton, Paul [6] , Nosten, Francois [5] , Ferdig, Mike [3] 1. Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA 2. Southwest Foundation for Biomedical Research, San Antonio, TX, USA 3. Notre Dame University, South Bend, IN, USA 4. Queens University, Kingston, Canada 5. Shoklo Malaria Research Unit, Mae Sot, Thailand 6. Mahosot Hospital, Vientiane, Lao PDR Allosteric activation of trypanosomatid S-adenyosylmethionine decarboxylase by a catalytically dead homolog* Willert, Erin K [1] , Fitzpatrick, Richard [2] , Phillips, Margaret A [,1] 1. Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA 2. Genzyme Drug and Biomaterial R&D, Waltham, MA, USA An atypical P. falciparum* ETRAMP interacts with human apolipoproteins** Vignali, Marissa [1] , Gridasova, Anastasia [2] , LaCount, Doug J [1] , Chettier, Rakesh [3] , Bell, Russel [3] , Sahasrabudhe, Sudhir [3] , Hughes, Robert E [3] , Fields, Stanley [,2] 1. Departments of Genome Science and Medicine, University of Washington, Seattle, U.S. 2. Departments of Genome Science and Medicine, University of Washington/HHMI, Seattle, WA, U.S. 3. Prolexys Pharmaceuticals, Inc., Salt Lake City, UT, U.S. An Inducible Destabilization Domain Modulates Protein Levels in Plasmodium falciparum* Armstrong, Christopher M., Goldberg, Daniel E. [] Molecular Microbiology, Washington University School of Medicine, St. Louis, USA Analysis of evolution of Plasmodium on the level of population genetics Sex and Deception: the forces on the genome of the malaria parasite* Kaczanowski, Szymon [,1] , Shahid, Khan [2] , Waters, Andy P [2] , Janse, Chris [2] , Hartl, Daniel [3] 1. Bioinformatics, institute of Biochemistry and Biophysics PAS, Warszawa, Poland 2. LUMC, Leiden, The Netherlands 3. Departments of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, United States Analysis of Human Serum Resistant Trypanosoma brucei brucei* Kieft, Rudo , Faulkner, Sara , Hajduk, Stephen [] Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA Analysis of protein trafficking in Plasmodium knowlesi* Comeaux, Christy A, Refour, Philippe , Marti , Matthias , Duraisingh, Manoj T. [] Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA Analysis of Trypanosoma brucei* Origin Recognition Complex** Vandoros, Anthula V, Mozeleski, Brian , Klingbeil, Michele M [] Microbiology, University of Massachusetts, Amherst, Amherst, MA, United States Analysis of variant gene families in Plasmodium knowlesi* Boehme, Ulrike [,1] , Berry, Andrew , Pain, Arnab [1] , Mungall, Karen [1] , Pasini, Erica [2] , Kocken, Clemens [2] , Mistry, Jaina [1] , Meyer, Irmtraud [3] , Thomas, Alan [2] , Rajandream, Marie-Adèle [1] , Barrell, Bart [1] , Berriman, Matt [1] 1. Wellcome Trust Sanger Institute, Cambridge, UK 2. Biomedical Primate Research Centre, Rijswijk, The Netherlands 3. Michael Smith Laboratories, 2185 East Mall, Canada Anchoring of the myosin-A motor complex in the Toxoplasma inner membrane complex* Beckers, Con [] , Johnson, Terezina UNC-Chapel Hill, Chapel Hill, NC, USA Anti-trypanosomal activity of topoisomerase IB-targeting indenoisoquinolines* Bakshi, Rahul P [1] , Sang, Dongpei [1] , Morrell, Andrew [2] , Cushman, Mark [2] , Shapiro, Theresa A [,1] 1. Medicine/Clinical Pharmacology, Johns Hopkins University, Baltimore, MD, USA 2. Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA Apicoplast Isoprenoid Biosynthesis in Toxoplasma gondii: Understanding the mechanism of fosmidomycin resistance* Nair, Sethu , Stroupe, Adam , Moreno, Silivia , Striepen, Boris [] Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602 Artemisinin Derivatives Accumulate within Digestive Vacuole-Associated Neutral Lipid Bodies in Plasmodium falciparum* Hartwig, Carmony Leah [1] , Rosenthal, Andrew S [2] , D Angelo, John [2] , Posner, Gary H [2] , Cooper, Roland A [,1] 1. Biology, Old Dominion University, Chesapeake, VA, United States 2. Chemistry, Johns Hopkins University, Baltimore, MD, United States Assessment of the MSF Assay for Malaria In Vitro* Drug Combination Screening and Mixed Strain Infections** Johnson, Jacob Daniel [] , Dennull, Richard , Reinbold, Drew , Cortes, Edison , Waters, Norman Experimental Therapeutics, Parasitology, Walter Reed Army Institute of Research, Silver Spring, MD, USA Autophagy is necessary for differentiation of Leishmania major* Williams, Roderick Adeyinka Malcolm [1] , Mottram, Jeremy C [1] , Coombs, Graham H [,2] 1. Wellcome Centre of Molecular Parasitology, University of Glasgow, Glasgow, VA, Scotland 2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK C Calreticulin- and collectin-dependent Entamoeba histolytica* phagocytosis** Teixeira, Jose E., Heron, Bradley T., Huston, Christopher D. [] Medicine, University of Vermont College of Medicine, Burlington, VT, USA Cell-free Expression of P. falciparum* Enzymes in Functional Form** Mudeppa, Devaraja G, Rathod, Pradipsinh K [] University of Washington, Seattle, USA Changes in global metabolites of Plasmodium falciparum* with erythrocyte development and antimalarial drugs** Pisciotta, John M [,1] , Tripathi, Abhai K. [1] , Ogunbiyi, Oluwatosin [1] , Rasoloson, Dominique [1] , Shuman, Joel [2] , Shulaev , Vladimir [2] , Sullivan, David J [1] 1. MMI, Johns Hopkins , Baltimore, MD, USA 2. Virginia Bioinformatics Institute, Blacksburg, VA, USA Characterisation of Eukaryotic Initiation Factor 2 alpha stress-responsive kinases in Plasmodium falciparum* Fennell, Clare , Doerig, Christian [] Wellcome centre for molecular parasitology, Glasgow University, Glasgow, UK Characterisation of proteases involved in the haemoglobin digestion cascade in the human hookworm Necator americanus* Ranjit, Najju [,1] , Stenzel, Deb [2] , Loukas, Alex [1] 1. Immunology and Infectious diseases, Queensland Institute of Medical Research, Brisbane, Australia 2. Queensland Institute of Technology, Brisbane, Australia Characterisation of the flavodiiron protein from Trichomonas vaginalis* hydrogenosomes** Smutna, Tamara [] , Hrdy, Ivan [] Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic Characterisation of the mitochondrial ATP synthase/hydrolase complex of the model protist Tetrahymena thermophila Nina, Praveen Balabaskaran, Mather, Michael W, Ke, Hangjun , Maddur Ganesan, Suresh , Vaidya, Akhil B [] Microbiology and Immunology, Drexel university college of medicine, Philadelphia, USA Characterization and Crystallization of the Plasmodium falciparum* ubiquitin/Nedd8 protease UCHL3** Artavanis-Tsakonas, Katerina [1] , Weihofen, Wilhelm [2] , Gaudet, Rachelle [2] , Ploegh, Hidde L. [,1] 1. Biology, Whitehead Institute for Biomedical Research, Cambridge, MA, USA 2. Department of Molecular and Cellular Biology, Harvard, Cambridge, MA, USA Characterization of a new family of Toxoplasma gondii* surface antigens** Pollard, Angela M. [1] , Onatolu, Krystal N. [1] , Hiller, Luisa [2] , Haldar, Kasturi [2] , Knoll, Laura J. [,1] 1. Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA 2. Northwestern University, Chicago, IL, USA Characterization of a Novel WRKY-like Gene in Giardia lamblia* Kao, yu-yun , Sun, Chin-Hung [] Department of Parasitology, College of Medicine, National Taiwan University, Taipei, Taiwan Characterization of a Putative Kinesin in Trypanosoma brucei* Engelson, Erin J [] , Van Voorhis, Wes Medicine, University of Washington, Seattle, WA, United States Characterization of a Soluble Pyrophosphatase from Toxoplasma gondii* (TgSP)** Fang, Jianmin [] , Docampo, Mellisa D., Moreno, Silvia N.J. Cellular Biology, University of Georgia, Athens, GA, USA Characterization of a UBC13 kinase in Plasmodium falciparum* Philip, Nisha [1] , Haystead, Timothy [,2] 1. Institute of Genomic Sciences and Policy, Duke University, Durham, NC, USA 2. Pharmacology and Cancer Biology, Duke University, Durham, NC, USA Characterization of Cryptosporidium* mucin antigens CpMuc4 and CpMuc5.** OConnor, Roberta M [,1] , Scarpato, Kristen [1] , Ha-Ngoc, Tin [1] , Burns, Patrick [1] , Kang, Gagandeep [2] , Ward, Honorine [1] 1. Geographic Medicine and Infectious Diseases, Tufts-New England Medical center, Boston, USA 2. Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India Characterization of mitochondrial DNA polymerase complexes in Trypanosoma brucei* Concepción, Jeniffer , Laitinen, Karen , Sarmiento, Rose , Klingbeil, Michele M [] Microbiology, University of Massachusetts, Amherst, MA, United States Characterization of mitosome-like organelle in Mastigamoeba balamuthi* Nyvltova, Eva [,1] , Dykova, Iva [2] , Hrdy, Ivan [1] , Tachezy, Jan [,1] 1. Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic 2. Institute of Parasitology, Czech Academy of Science, Ceske Budejovice, Czech Republic Characterization of Promoter-trap Insertional Mutants in Toxoplasma gondii Pszenny, Viviana [1] , Dzierszinski, Florence [2] , Beiting, Daniel P [1] , Davis, Paul H [1] , Hunter, Christopher A [3] , Roos, David S [,1] 1. Biology, University of Pennsylvania, Philadelphia, PA, USA 2. McGill University, Montreal, Canada 3. Pathobiology - School of Veterinary, University of Pennsylvania, Philadelphia, PA, USA Characterization of rhomboid proteases in Entamoeba histolytica* identifies a catalytically active protease with novel substrate specificity and regulated localization associated with phagocytosis** Baxt, Leigh [1] , Baker, Rosanna [2] , Pompey, Justine [1] , Singh, Upinder [,1] , Urban, Sinisa [,2] 1. Microbiology and Immunology, Stanford University, Menlo Park, USA 2. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA Characterization of the ApiAP2 DNA-binding proteins in Plasmodium falciparum De Silva, Erandi K [1] , Chahal, Jasdave S [1] , Leon, Ilsa [1] , Gehrke, Andrew [2] , Bulyk, Martha L [3] , Llinas, Manuel [,1] 1. Department of Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA 2. Division of Genetics, Department of Medecine, Harvard Medical School, Boston, MA, USA 3. Division of Genetics, Department of Medecine, Harvard/MIT Division of Health Sciences & Technology, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA Characterization of the Early Liver Stage Transcriptome in P. falciparum* Speake, Cate [,1] , Juompan, Laure [2] , Siwo, Geoffrey [3] , Sivam, Dhileep [4] , Chalom, Isaac [2] , Chen, Jingyang [4] , de la Vega, Patricia [2] , Williams, Jackie [2] , Kappe, Stefan H. I. [4] , Heppner, D. Gray [2] , Krzych, Urszula [2] , Duffy, Patrick E. [4] 1. University of Washington, Department of Pathobiology, Seattle, WA, USA 2. Walter Reed Army Institute of Research, Silver Spring, MD, USA 3. Department of Biochemistry and Molecular Biology, Egerton University, Egerton, Kenya 4. Seattle Biomedical Research Institute, Seattle, WA, USA Characterization of the Giardia intestinalis* mitosomal processing peptidase** Smid, Ondrej [,1] , Matuskova, Anna [2] , Zubacova, Zuzana [1] , Harris, Simon [3] , Janata, Jiri [2] , Hrdy, Ivan [1] , Tachezy, Jan [1] 1. Faculty of Science, Charles University, Prague, Czech Republic 2. Academy of Sciences of the Czech Republic, Prague, Czech Republic 3. University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom Characterization of the Lipoate Synthase from Plasmodium falciparum* Gisselberg, Jolyn E. [1] , Allary, Marina [2] , Sneedorff, Jennifer [3] , Booker, Squire J. [4] , Prigge, Sean T. [,2] 1. Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2. Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 3. Biology, Johns Hopkins University, Baltimore, MD, USA 4. Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA Characterization of the Plasmodium falciparum* acylaminoacyl peptidase** Ricaldez, Ericka X, Goldberg, Daniel E. [] Medicine and Molecular Microbiology, Howard Hughes Medical Institute/ Washington University School of Medicine, Saint Louis, MO, United States Characterization of the Potential RNA Editing Factor TbRGGm in Trypanosoma brucei.* Fisk, John C [] , Read, Laurie K Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA Characterization of TOR genes in bloodstream T. brucei* Anderson, Sedrick [1] , Faulkner, Sara D [1] , Hajduk, Stephen L [1] , Campbell, Robert K [,2] 1. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA 2. Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA Characterization of Trypanosoma brucei* sphingolipid synthases** Sutterwala, Shaheen [,1] , Hsu, Fong Fu [2] , Turk, John [2] , Bangs, James [1] 1. Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA 2. Division of Metabolism, Endocrinology, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA Characterization of two putative flagellar genes in Trypanosoma brucei* Pernas, Lena F [1] , Hare, Julie D [2] , Ralston, Katherine S [1] , Kabututu, Zayaki P [1] , Springer, Amy [2] , Hill, Kent L [1] 1. Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, United States 2. Department of Biological Sciences, Mount Holyoke College, South Hadley, MA, United States Chemically mapping protease pathways involved in the regulation of erythrocyte rupture by the human malaria parasite Plasmodium falciparum Arastu-Kapur, Shirin [1] , Ponder, Elizabeth L. [2] , Fonovic, Ursa Pecar [1] , Yeoh, Sharon [3] , Yuan, Fang [2] , Fonovic, Marko [2] , Grainger, Munira [3] , Drew, Mark E. [4] , Phillips, Carolyn I. [2] , Powers, James [5] , Bogyo, Matthew [,1] 1. Pathology, Stanford University, Stanford, CA, USA 2. Microbiology and Immunology, Stanford University, Stanford, CA, USA 3. Parasitology, National Institute for Medical Research, London, UK 4. Molecular Microbiology, Washington University, St. Louis, MO, USA 5. Chemistry, Georgia Institute of Technology, Atlanta, GA, USA Clonal conditional mutagenesis in P. berghei* Combe, Audrey [1] , Giovannini, Donatella [1] , Gil Carvalho, Teresa [1] , Thiberge, Sabine [1] , Lacroix, Céline [1] , Bhanot, Purnima [2] , Menard, Robert [,1] 1. Biologie et Génétique du Paludisme, Institut Pasteur, Paris, France 2. Microbiology and Molecular Genetics, UMDNJ, Newark, NJ, USA C Combined chemical and genomic characterization of a Plasmodium falciparum calcium-dependent protein kinase reveals a role in invasion* Kato, Nobutaka [,1] , Le Roch, Karine G [1] , Sakata, Tomoyo [1] , Nagle, Advait [1] , McNamara, Case [1] , Plouffe, David [1] , Ward, Gary E [2] , Gray, Nathanael [1] , Harper, Jeffrey [3] , Winzeler, Elizabeth A [,1] 1. Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA 2. Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA 3. Biochemistry Department, University of Nevada, Reno, NV, USA Comparative analysis of trichomonad genome sizes and karyotypes Zubacova, Zuzana [,1] , Cimburek, Zdenek [2] , Hovorka, Ondrej [2] , Tachezy, Jan [,1] 1. Department of Parasitology, Faculty of Science, Charles University, Prague 2, Czech Republic 2. Institute of Microbiology, Academy of Sciences of the Czech Republic , Prague, Czech Republic *Comparative Genome Hybridization and Gene Expression Profiling using Plasmodium vivax* Whole Genome Tiling Microarrays** Westenberger, Scott J [] , Dharia, Neekesh V, Winzeler, Elizabeth A Cell Biology, The Scripps Research Institute, La Jolla, CA, USA Conserved and novel trypanosome RNA metabolic enzymes are substrates for arginine methylation* Menon, Sarita G [] , Pasternack, Deborah A, Read, Laurie K Microbiology and Immunology, University of Buffalo, Buffalo, NY, USA Conserved structural motifs within the antigenically variant CKRD domain of the VESA1 protein of Babesia bovis* Zupanska, Agata K, Drummond, Paul B, Al-Khedery, Basima , Allred, David R [] Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA CONTRIBUTION OF SPECIES-SPECIFIC GENES TO DISEASE TROPISM IN VISCERAL LEISHMANIASIS* Hilley, Jim D [1] , Saad, Walide [1] , Peacock, Christopher S [2] , Kaye, Paul M [3] , Smith, Deborah F [3] , Mottram, Jeremy C [,1] 1. Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, Scotland 2. The Wellcome Trust Sanger Institute, Cambridge, United Kingdom 3. Department of Biology, University of York, York, United Kingdom Cyclin Dependent Kinase (CDK) activity and DNA synthesis in the malaria parasite; a possible connection.* Co, Edgie-Mark [1] , Jirage, Dayadevi [1] , Eyase, Frederick [1] , Dennull, Richard A. [1] , Caridha, Diana [1] , Waters, Norman C. [,2] 1. Parasitology, Walter Reed Army Institute of Research, Silver Spring, MD, USA 2. Australian Army Malaria Institute, Enogerra, QLD, USA Cyst formation in Giardia duodenalis is affected by phoshorylation and polyglycylation of 14-3-3 homolog protein* Lalle, Marco [,1] , Fratini, Federica [2] , Bavassano, Carlo [1] , Cecchetti, Serena [3] , Marco, Crescenzi [2] , Pozio, Edoardo [1] 1. Infectious Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy 2. Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy 3. Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy D Detecting and validating novel non-coding RNA gene candidates in Plasmodium falciparum* Pineda, Fernando J [] , Wu, Gang , Maciel, Jorge E, Nirbhay, Kumar Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Development of a Fluorescence-Based RNAi Library Screen for Mutants in Fatty Acid Uptake* McCall, Barbara , McCallister, Jennifer , Paul, Kimberly [] Biological Sciences, Clemson University, Clemson, SC, USA Development of a pan-rodent long oligonucleotide microarray for global genomics and transcriptomic study of Plasmodium yoelii, Plasmodium berghei* and Plasmodium chabaudi** Liew, Kingsley , Hu, Guangan , Bozdech, Zbynek , Preiser, Peter [] School of Biological Sciences, Nanyang Technological University, Singapore, Singapore Development of a system to assess in situ* switching in the Babesia bovis locus of active ves transcription (LAT)** Wang, Xinyi , Allred, David [] Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA Development on an in vivo* biotinylation system for Plasmodium falciparum** Horrocks, Paul [] Keele University Medical School, Staffordshire, United Kingdom Direct inhibition of caspase-9 activity by Toxoplasma gondii in vitro* may reveal new mechanisms to prevent apoptosis in infected host cells** Shen, Aimee [,1] , Salvesen, Guy [2] , Bogyo, Matthew [1] 1. Pathology, Stanford, Stanford, CA, USA 2. Burnham Institute for Medical Research, La Jolla, CA, USA Discharge of an essential serine protease from novel organelles mediates release of invasive malaria parasites from the host erythrocyte* Yeoh, Sharon [1] , O Donnell, Rebecca A [1] , Koussis, Konstantinos [1] , Dluzewski, Anton R [1] , Ansell, Keith H [2] , Osborne, Simon [2] , Hackett, Fiona [1] , Withers-Martinez, Chrislaine [1] , Mitchell, Graham H [3] , Bryans, Justin S [2] , Kettleborough, Catherine A [2] , Bannister, Lawrence H [3] , Blackman, Michael J [,1] 1. National Institute for Medical Research, London, UK 2. Medical Research Council Technology, London, UK 3. Guys, Kings and St Thomas Hospital, London, UK Disruption of a gene coding for a putative splicing factor prevents bradyzoite differentiation in Toxoplasma gondii* Thompson, Belinda , Matrajt, Mariana [] Microbiology and Molecualar Genetics, University of Vermont, Burlington, VT, USA Disruption of Plasmodium* hmgb2 gene reveals its role as a master regulator of oocyst development** Gissot, Mathieu [,1] , Ting, Li-Min [1] , Daly, Thomas M [2] , Bergman, Lawrence M [2] , Voza, Tatiana [3] , Sinnis, Photini [3] , Kim, Kami [1] 1. Medicine / Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY, USA 2. Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA 3. Medical and Molecular Parasitology, New York University School of Medicine, New York, NY, USA Disruption of the enoyl-ACP reductase fatty acid enzyme results in reduced virulence of Plasmodium* sporozoites** Yu, Min [1] , Coppi, Alida [2] , Kumar, T. R. Santha [3] , Jacobs, Jr., William R. [4] , Sacchettini, James C. [5] , Sinnis, Photini [2] , Fidock, David A. [,1] 1. Microbiology, Columbia University, New York, USA 2. Medical Parasitology, New York University, New York, NY, USA 3. Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA 4. Microbiology and Immunology and HHMI, Albert Einstein College of Medicine, New York, NY, USA 5. Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA Dissection of Toxoplasma gondii* host cell invasion through egress mutants** Eidell, Keith P. [1] , Burke, Thomas [1] , Striepen, Boris [2] , Gubbels, Marc Jan [,1] 1. Biology, Boston College, Chestnut Hill, MA, USA 2. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA DNA methylated binding complex in Entamoeba histolytica* Lavi, Tal [] , Siman-Tov, Rama , Serge, Ankri Molecular Microbiology, Faculty of Medicine, The Technion Institute, Haifa, Israel DNA Mismatch Repair in Plasmodium falciparum: Possible Mechanism for Accelerated Drug Resistance* Castellini, Meryl , Buguliskis, Jeff , Taraschi, Theodore F. [] Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States E Early Events During Bradyzoite Differentiation in T. gondii* Davis, Paul H [1] , Bahl, Amit [1] , Beiting, Daniel P [1] , Dzierszinski, Florence S [2] , Roos, David S [,1] 1. Biology, University of Pennsylvania, Philadelphia, PA, USA 2. Parasitology, McGill University, Montreal, Canada Elucidation of transcriptional regulatory sites involved in the heat shock response of Cryptosporidium hominis* Cohn, Benjamin L [,1] , Manque, Patricio A [1] , Serrano, Myrna G [1] , Lara, Ana M [1] , Sheth, Nihar [2] , Buck, Gregory A [1] 1. Microbiology & Immunology, Virginia Commonwealth University, Richmond, VA, USA 2. Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA Energy production in Toxoplasma gondii* during parasite-host cell interaction** Pomel, Sebastien [] , Beckers, Con Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC, USA Enoyl-ACP Reductase (FabI). An Antimalarial Target* Mendoza, Alfonso [,1] , Rodriguez, Ane [1] , Gomez, Maria G [1] , Lopez, Eva M [1] , De Cozar, Cristina [1] , Sanz, Laura [1] , Gamo, Francisco J [1] , Castro, Julia [1] , Barros, David [1] , Sacchettini, James [2] , Fidock, David A [3] , Garcia-Bustos, Jose F [1] 1. DDW, GlaxoSmithKline, Tres Cantos, Spain 2. Texas A&M University, College Station, TX, USA 3. Columbia University, New York, NY, USA Evidence for karyogamy and exchange of genetic material in the binucleate intestinal parasite Giardia intestinalis* Carpenter, Meredith L, Poxleitner, Marianne K, Mancuso, Joel , Cande, W. Zacheus [] Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA Evidence for Prenylation-dependent Targeting of a Novel Ykt6 SNARE Homologue from Plasmodium falciparum* to Golgi-like Structures** Barrero-Tobon, Angelica [1] , Ayong, Lawrence [1] , DaSilva, Thiago [1] , Fidock, David [2] , Allen, Charles [3] , Chakrabarti, Debopam [,1] 1. Molecular Biology & Microbiology, University of central Florida, Orlando, FL, USA 2. Microbiology, Columbia University, New York, NY, USA 3. Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, USA Expression of a Second Serum Resistance Associated (SRA) Gene Near a Metacyclic Expression Site in Trypanosoma brucei rhodesiense* Shiflett, April M, Milner, Jeffrey D, Yermovsky-Kammerer, Audra E., Kieft, Rudo , Hajduk, Stephen L. [] Biochemistry & Molecular Biology, University of Georgia, Athens, GA, USA Expression of putative cysteine proteases of the SERA family during the liver stage of Plasmodium berghei* Schmidt-Christensen, Anja [,1] , Sturm, Angelika [1] , Menard, Robert [2] , Giovannini, Donatella [2] , Heussler, Volker [1] 1. Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany 2. Institut Pasteur, Paris, France Expression Profiling of Early Immunity in Rodent Malaria* Kim, Charlie [,1] , Parikh, Sunil [2] , Myrick, Alissa [2] , Rosenthal, Philip [2] , DeRisi, Joseph [1] 1. Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA 2. Medicine, University of California, San Francisco, San Francisco, CA, USA F Face to face: Characterization of the secretory pathway in Plasmodium falciparum* Herrmann, Susann [1] , Struck, Nicole S. [1] , Schmuck-Bergmann, Iris [1] , de Souza Dias, Suzana [1] , Cowman, Alan F. [2] , Spielmann, Tobias [1] , Gilberger, Tim W. [,1] 1. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany 2. Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia Falcipains activate the P. falciparum* plasmepsins** Drew, Mark E., Goldberg, Daniel E. [] Molecular Microbiology, Washington University/HHMI, St. Louis, MO, USA Farnesyl pyrophosphate synthase is a peak function enzyme in Leishmania donovani promastigotes* Srivastava, Anuradha [,1] , Pradhan, Anupam [1] , Baerson, Scott [2] , Pan, Zhiqiang [2] , Tekwani, Babu L. [1] 1. Natural Products Center, School of Pharmacy, University of Mississippi, University, MS, United States 2. USDA-ARS, National Center for Natural Products Research , University, MS, USA Four Distinct Pathways of Hemoglobin Uptake in the Malaria Parasite Plasmodium falciparum* Elliott, David A [,1] , McIntosh, Michael T [2] , Hosgood, H Dean [3] , Chen, Shuo [1] , Zhang, Gina [1] , Baevova, Pavlina [3] , Joiner, Keith A [1] 1. Cell Biology and Anatomy, University of Arizona College of Medicine, Tucson, AZ, USA 2. Plum Island Animal Disease Center , Greenport, NY, USA 3. Infectious Disease, Yale University School of Medicine, New Haven, CT, USA Frataxin is the essential protein in FeS cluster biosynthesis in mitochondria and hydrogenosomes* Mach, Jan [,1] , Long, Shaojun [2] , Jirku, Milan [2] , Dolezal, Pavel [1] , Lukes, Julius [2] , Tachezy, Jan [1] 1. Department of Parasitology, Faculty of Science, Charles University, Prague 2, Czech Republic 2. Institute of Parasitology, Czech Academy of Science, Ceske Budejovice, Czech Republic Function of protein prenylation in the correctly protein localization in Plasmodium falciparum* D Alexandri, Fabio Luiz [,1] , Wunderlich, Gerhard [1] , Becerra, Maria Del Carmen Fernandez [1] , Mortara, Renato Arruda [2] , Dutra, Marcos Gazarine [2] , Kimura, Emilia Akemi [1] , Katzin, Alejandro Miguel [1] 1. Department of Parasitology, University of São Paulo, São Paulo, Brazil 2. Department of Microbiology, Imunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil Functional analysis of inner arm dynein and radial spoke knockdowns in Trypanosoma brucei* Kinzel, Kathryn W, Rosenthal, Noël F, Springer, Amy L [] Biological Sciences, Mount Holyoke College, South Hadley, MA, USA G Generation of Plasmodium berghei* mutants deficient in expression of glutathione reductase** Pastrana-Mena, Rebecca [1] , Vega-Rodríguez, Joel [1] , Colón Rivera, Héctor A [1] , Franke-Fayard, Blandine [2] , Delgado-Morales, Wilfredo [3] , Rodríguez-Orengo, José [3] , Waters, Andrew P [2] , Janse, Chris J [2] , Serrano, Adelfa E [,1] 1. Microbiology, UPR Medical Sciences Campus, San Juan, Puerto Rico 2. Parasitology, Leiden University Medical Center, Leiden, The Netherlands 3. Biochemistry, UPR Medical Sciences Campus, San Juan, Puerto Rico GENETIC IDENTIFICATION OF ESSENTIAL INDELS AND DOMAINS IN CARBAMOYL PHOSPHATE SYNTHETASE II OF TOXOPLASMA GONDII* Fox, Barbara A. [] , Gagnon, Jessica S., Bzik, David J. Microbiology and Immunology, Darmouth Medical School, Lebanon , NH, USA Genomic distribution of histone H3 trimethylated at Lys 4 in the human parasite Trypanosoma cruzi* Respuela, Patricia , Aslund, Lena [] Genetics and Pathology, Uppsala, Sweden Genotyping P. falciparum* reveals population differences enriched for amino acid substitutions with greater genetic diversity in Senegal compared to Thailand** Volkman, Sarah K. [1] , Neafsey, Daniel E. [2] , Sabeti, Pardis C. [2] , Park, Daniel J. [2] , Schaffner, Stephen F. [2] , Milner, Danny A. [1] , Lukens, Amanda K. [1] , Montgomery, Phil [2] , Gates, Casey [2] , Houde, Nathan [2] , Daily, Johanna P. [1] , Sarr, Ousmane [3] , Ndiaye, Daouda [3] , Mboup, Soulyemane [3] , Wiegand, Roger [2] , Hartl, Daniel L. [4] , Birren, Bruce W. [2] , Galagan, James E. [2] , Lander, Eric S. [2] , Wirth, Dyann F. [,1] 1. Harvard School of Public Health, Boston, MA, USA 2. The Broad Institute of MIT and Harvard, Cambridge, MA, USA 3. Faculty of Medicine and Pharmacy, Cheikh Anta Diop University , Dakar, Senegal 4. Harvard University, Cambridge, MA, USA Global analysis of the variant gene repertoire of Plasmodium falciparum* points to a small but disperse South American-Amazonian repertoire** Albrecht, Letusa [] , Mattos, Ricardo GF, Castineiras, Catarina , Wunderlich, Gerhard Department of Parasitology, University of São Paulo, São Paulo, Brazil Global metabolomic responses to antimalarial drugs* Olszewski, Kellen [1] , Rabinowitz, Joshua [2] , Llinas, Manuel [,1] 1. Molecular Biology & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA 2. Chemistry & Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA Global transcriptional activity regulated stage-specifically during Plasmodium falciparum* development in the RBC** Sims, Jennifer S [1] , Militello, Kevin T [2] , Sims, Peter A [3] , Patel, Vishal P [1] , Kasper, Jacob M [1] , Wirth, Dyann F [,1] 1. Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA 2. Department of Biology, SUNY Geneseo, Geneseo, NY, USA 3. Harvard University, Cambridge, MA, United States Global Transcriptional Profiling of the Effects of Antimalarial Drug Action and Drug-dosage on Plasmodium falciparum* mok, sachel , Bozdech, Zbynek [] School of Biological Sciences, Nanyang Technological University, Singapore, Singapore Global Transcriptional Responses of Plasmodium falciparum* to small molecular inhibitors** Chaal, Balbir Kaur [] , Wastuwidyaningtyas , Brigitta Dewi, Bozdech, Zbynek SCHOOL OF BIOLOGICAL SCIENCES, NANYANG TECHNOLOGICAL UNIVERSITY, SINGAPORE, SINGAPORE Globally identifying mutations in Plasmodium falciparum* using high-density tiling microarrays** Dharia, Neekesh V [] , Westenberger, Scott , Winzeler, Elizabeth A The Scripps Research Institute, La Jolla, CA, US Globe search of PfGCN5 mediated Genes in Plasmodium falciparum using two HAT inhibitors* Cui, Long [1] , Miao, Jun [1] , Furuya, Tetsuya [2] , Su, Xin-zhuan [2] , Cui, Liwang [,1] 1. Department of Entomology, Penn State University, University Park, PA, USA 2. NIAID, NIH, Bethesda, MD, USA Glycogen Synthase Kinase 3 is a Potential Drug Target for African Trypanosomiasis Therapy* Ojo, Kayode K. [1] , Riechers, Aaron J. [1] , Napuli, Alberto J. [2] , Karimi, Mandana [1] , Rivas, Kasey L. [1] , Gillespie, J. Robert [1] , Barrett, Lynn K. [1] , Verlinde, Christophe L. M. J. [2] , Buckner, Frederick S. [1] , Domostoj, Mathias [3] , Wells, Sue [3] , Wells, Tim [3] , Van Voorhis, Wesley C. [,1] 1. Medicine, University Of Washington, Seattle, USA 2. University of Washington, Seattle, WA, USA 3. Merck Serono International S.A., Genève, Switzerland H Hemoglobin Binding to Haptoglobin-Related Protein Stimulates Trypanosome Lytic Factor Binding to Trypanosomes and Induces Lysosomal Membrane Disruption* Widener, Justin W [1] , Nielsen, Marianne Jensby [2] , Shiflett, April [3] , Moestrup, Soren Kragh [2] , Hajduk, Stephen L [,3] 1. Pathobiology, Marine Biological Laboratory/Brown university, Providence, RI, USA 2. Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark 3. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA Higher-order structure in the Babesia bovis* locus of active ves transcription** Huang, Yingling , Allred, David R [] Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA Human lytic HDL uptake by Trypanosoma brucei brucei* is mediated by a haptoglobin-haemoglobin receptor** Vanhollebeke, Benoit [1] , Nielsen, Marianne J. [2] , De Muylder, Géraldine [1] , Pays, Annette [1] , Tebabi, Patricia [1] , Dieu, Marc [3] , Moestrup, Soren K. [2] , Pays, Etienne [,1] 1. IBMM, Université Libre de Bruxelles, Gosselies, Belgium 2. University of Aarhus, Aarhus, Denmark 3. University of Namur, Namur, Belgium I Identification and Characterization of Two 14-3-3 Proteins in Trypanosoma cruzi* Peel, Bethany A, Sturtevant, Joy E [] Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA Identification and functional characterization of proteins in the Aurora-B kinase complex from Trypanosoma brucei* Li, Ziyin [1] , Lee, Ju Huck [2] , Chu, Feixia [1] , Burlingame, Alma L [1] , Gunzl, Arthur [2] , Wang, C C [,1] 1. UCSF, San Francisco, CA, U. S. A. 2. University of Connecticut Health Center, Farmington, CT, U.S.A. Identification of a highly conserved AAA nucleotide binding domain in the Reticulocyte Binding Protein Homologues of Plasmodium* Ramalingam, Jeya Kumar [1] , Hunke, Cornelia [1] , Khan, Shahid [2] , Grüber, Gerhard [1] , Preiser, Peter Rainer [,1] 1. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore 2. Leiden University Medical Centre, Leiden, Netherlands IDENTIFICATION OF A MALARIAL PROTEASE FAMILY INVOLVED IN RUPTURE FROM THE HOST ERYTHROCYTE BY A CHEMICAL GENETICS APPROACH* Greenbaum, Doron C [,1] , Darling, Claire [1] , Chandramohanadas, Rajesh [1] , Chen, Kevin [1] , Zbynek, Bozdech [2] , Grainger, Munira [3] , Holder, Anthony [3] , Mccoubrie, Joanne [4] 1. Pharmacology, University of Pennsylvania, Philadelphia, PA, USA 2. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore 3. Division of Parasitology, NIMR, London, UK 4. Infection and Immunity, WEHI, Melbourne, Australia Identification of developmentally regulated genes in Entamoeba histolytica* Ehrenkaufer, Gretchen M, Singh, Upinder [] Microbiology and Immunology, Stanford University, Stanford, CA, USA Identification of genes essential for Toxoplasma gondii* cell morphology** Szatanek, Tomasz Artur, Flynn, Jayme , Rowinsky, Justin , Gubbels, Marc-Jan [] Biology, Boston College, Chestnut Hill, MA, USA Identification of host-pathogen protein interactions at the Toxoplama* parasitophorous vacuolar membrane** Reese, Michael L [] , Boothroyd, John C Microbiology & Immunology, Stanford University, Stanford, CA, USA Identification of novel cyclin E1/CRK1 substrates in Trypanosoma brucei* Gourguechon, Stephane [,1] , Blethrow, Justin D [2] , Allen, Jasmina J, Shokat, Kevan M [3] , Wang, CC [1] 1. department of pharmaceutical chemistry, university of california san francisco, san francisco, CA, usa 2. graduate program in chemistry and chemical biology, university of california san francisco, san francisco, CA, usa 3. Howard Hughes medical institute and department of cellular and molecular pharmacology, university of california san francisco, san francisco, CA, usa Identification of novel genes under diversifying selection in Plasmodium falciparum* Lukens, Amanda K. [,1] , Neafsey, Daniel E. [2] , Schaffner, Stephen F. [2] , DeCaprio, David [2] , Volkman, Sarah K. [1] , Sabeti, Pardis C. [2] , Park, Daniel J. [2] , Milner, Danny A. [1] , Daily, Johanna P. [1] , Sarr, Ousmane [3] , Ndiaye, Daouda [3] , Ndir, Omar [3] , Mboup, Soulyemane [3] , Wiegand, Roger C. [2] , Birren, Bruce W. [2] , Galagan, James E. [2] , Lander, Eric S. [2] , Wirth, Dyann F. [1] 1. Immunology and Infectious Diseases, Harvard School of Public Health, Boson, MA, USA 2. The Broad Institute of MIT and Harvard, Cambridge, MA, USA 3. Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal Identification of parasite virulence determinants reveals a unique RCC1 ortholog and uncovers an unusual nuclear transport machinery specific to protozoa* Frankel, Matthew B [1] , Mordue, Dana G. [2] , Knoll, Laura J. [,1] 1. Medical Microbiology and Immunology, University of Wisconsin-Madison, madison, WI, USA 2. Microbiology and Immunology, New York Medical College, Valhalla, NY, USA Identification of targets phosphorylated by the major Toxoplasma* virulence factor ROP18** Fentress, Sarah J., Taylor, Sonya , Beatty, Wandy L., Sibley, L. David [] Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA Identification of telomerase RNA and characterization of telomerase activity in the human parasite Plasmodium falciparum* Chakrabarti, Kausik [1] , Pearson, Michael [1] , Grate, Leslie [1] , Komai, Yuta [2] , Ares, Manuel [,1] 1. Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA 2. Hughes Undergraduate Research Laboratory (HURL), University of California Santa Cruz, Santa Cruz, CA, USA In vitro and in vivo characterization of the Plasmodium berghei* 14-3-3 protein** Lalle, Marco [] , Pace, Tomasino , Bavassano, Carlo , Pozio, Edoardo Pozio , Ponzi, Marta Infectious Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy Increasing homologous recombination efficiency in Toxoplasma gondii* through manipulation of DNA repair pathways** Anderson-White, Brooke R. [] , van Agtmaal, Ellen , Bell, Rob , Stellwagen, Anne , Chuang, Jeffrey , Gubbels, Marc-Jan Biology, Boston College, Chestnut Hill, MA, USA Inhibition of glucosylceramide synthesis induces a cytokinesis arrest and blocks stage differentiation in Giardia lamblia* Sonda, Sabrina [] , Stefanic, Sasa , Hehl, Adrian B University of Zurich, zurich, switzerland Initial Characterization of a Putative Inositol Phosphorylceramide-specific Phospholipase C Mutant in Leishmania major* Zhang, Kai [] Biological Sciences, Texas Tech University, Lubbock, TX, USA Integration of genome structural variants with transcriptional variants in a P. falciparum* genetic cross reveals signatures of drug selection** Gonzales, Joseph M [1] , Patel, Jigar J [1] , Tan, Asako [1] , Rathod, Pradip K [2] , Ferdig, Michael T [,1] 1. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA 2. Department of Chemistry, University of Washington, Seattle, WA, USA Interaction of Plasmodium falciparum* Erythrocyte Membrane Protein 3 with the Red Blood Cell Membrane Skeleton** Waller, Karena L [,1] , Stubberfield, Lisa M [1] , Dubljevic, Valentina [1] , Nunomura, Wataru [2] , An, Xuili [3] , Mason, Anthony J [1] , Mohandas, Narla [3] , Cooke, Brian M [1] , Coppel, Ross L [1] 1. Microbiology, Monash University, Clayton, Australia 2. Biochemistry, Tokyo Womens Medical University, Tokyo, Japan 3. New York Blood Center, New York, NY, USA Interactions of the gametocyte protein Pfg27 with RNA and protein partners* Camarda, Grazia [,1] , Singh, Saurabh [2] , Salzano, Anna Maria [3] , Scaloni, Andrea [3] , Sharma, Amit [2] , Alano, Pietro [1] 1. Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy 2. International Cente for Genetic Engineering and Biotechnology, New Delhi, India 3. ISPAAM, National Research Council, Naples, Italy Intramembrane proteolytic cleavage of TgAMA1 is not necessary for host cell invasion* Parussini, Fabiola [1] , Mital, Jeffrey T [2] , Ward, Gary E [,1] 1. Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA 2. Rocky Mountain Laboratories. NIAID, National Institute of Health, Hamilton, MT, USA Investigating the role of mitochondrial RNA polymerase in erythrocytic stage Plasmodium falciparum* Ke, Hangjun , Painter, Heather J, Balabaskaran Nina, Praveen , Ganesan, Suresh , Morrisey, Joanne M., Mather, Michael W., Vaidya, Akhil B. [] Microbiology and Immunology, Drexel University, philadelphia, PA, USA Investigation of a RecQ like Helicase in Plasmodium falciparum* Lopez Barragan, Maria Jose [,1] , Ben Mamoun, Choukri [2] , Su, Xinzhuan [1] 1. LMVR, NIH, Rockville, MD, USA 2. University of Connecticut Health Center, Farmington, CT, USA Investigation of conserved exported Plasmodial proteins defines a core set* van Ooij, Christiaan [1] , Hiller, N. Luisa [2] , Tamez, Pamela A. [1] , Balu, Bharath [3] , Adams, John [3] , Ramesar, Jai [4] , Waters, Andy [4] , Janse, Chris [4] , Haldar, Kasturi [,1] 1. Pathology, Northwestern, Chicago, IL, USA 2. University of Pittsburgh, Pittsburgh, PA, USA 3. Global Health, University of Southern Florida, Tampa, FL, USA 4. Parasitology, Leiden University Medical Center, Leiden, The Netherlands Is the emergence of placental adhesion of P. falciparum-infected erythrocytes due to host factors present during pregnancy?* Nunes, Marta C, Scherf, Artur [] Parasitology, Institut Pasteur, Paris, France Kinase Activity of Entamoeba histolytica* Transmembrane Kinases (TMKs)** Solaymani-Mohammadi, Shahram [1] , Boettner, Douglas [2] , Frederick, Jesse [3] , Linford, Alicia , Petri, William [] 1. Infectious Diseases, University of Virginia, Charlotetsville, VA, USA 2. University of Virginia, Charlotetsville, USA 3. University of Virginia, charlottesville, USA K Kinesin-2 is critical for cytokinesis in the bloodstream form of Trypanosoma brucei* Douglas, Robert L. [1] , Haltiwanger, Brett M. [2] , Jeng, Robert L. [1] , Keenan, Alexandra [1] , Mancuso, Joel J. [1] , Cande, W. Zacheus [1] , Welch, Matthew D. [,1] 1. Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA 2. Agricultural Research Service, United States Department of Agriculture, Albany, CA, USA Knock down of spermidine synthetase and ornithine decarboxylase by RNAi in blood form T. brucei* provides insight into the regulation of the polyamine biosynthetic pathway** Xiao, Yanjing [] , Willert, Erin K, Phillips, Margaret A Dept. of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A Knockout mutants of Plasmodium falciparum* and P. berghei lacking the digestive vacuole plasmepsins are attenuated in blood stage growth** Bonilla, J. Alfredo [1] , Syphard, Luke M. [1] , Yowell, Charles A. [1] , Bonilla, Tonya D. [1] , Abbott, Jeffrey R. [1] , Crisanti, Andrea [2] , Janse, Chris J. [3] , Waters, Andrew P. [3] , Dame, John B. [,1] 1. Infectious Diseases and Pathology, University of Florida, Gainesville, USA 2. Biological Sciences, Imperial College London, London, UK 3. Parasitology, Leiden University Medical Center, Leiden, Netherlands KREPA4, an essential RNA binding protein is also part of a ternary editosome subcomplex interaction in Trypanosoma brucei* Kala, Smriti , Radojewski, Erica , Salavati, Reza [] Parasitology, McGill University, Quebec, Canada L Leishmania* CRK3:CYC6 cyclin-dependent kinase as a drug target Walker, Roderick G. [1] , Grant, Karen M. [2] , Thomson, Graeme [3] , Mottram, Jeremy C. [,1] 1. Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom 2. Centre for Medical Education, University of Lancaster, Lancaster, United Kingdom 3. Assay Department, Cyclacel Limited, Dundee, United Kingdom Leishmania major* Oligopeptidase B Munday, Jane C [,1] , Bland, Nicholas D [1] , Westrop, Gareth D [2] , Mottram, Jeremy C [1] , Coombs, Graham H [2] 1. Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow, UK 2. Strathcyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Leishmania Major* Orthologues of Mammalian Macrophage Migration Inhibitory factor (MIF) Morrison, Lesley S [,1] , Richardson, J. [2] , Bland, N. [1] , McGachy, A. [3] , Alexander, J. [3] , Walkinshaw, M. [2] , Coombs, G.H. [1] , Mottram, J.C. [1] 1. Wellcome Centre for Molecular Parasitology, Glasgow University, Glasgow, Scotland 2. The University of Edinburgh, Edinburgh, Scotland 3. University of Strathclyde, Glasgow, Scotland Lipidomic Analysis Reveals that Phosphatidylglycerols are Major Phospholipids in Giardia lamblia* Yichoy, Mayte [] , Nakayasu, Ernesto S, Almeida, Igor C, Das, Siddhartha , Aley, Stephen B Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, U.S.A. Localization and functional studies of the malaria Plasmepsins IX and X* Polonais, Valerie , Shea, Micheal , Pino, Paco , Soldati, Dominique [] Department of Microbiology and Molecular Medicine, University of Geneva, Faculty of Medecine, CMU, GENEVA 4, Switzerland Localization of a Phosphate Permease protein in rodent filarial nematode Litomosoides sigmodontis* Arumugam, Sridhar [] , Pfarr, Kenneth M , Hoerauf, Achim Institute for Medical Microbiology, Immunology and Parasitology, bonn, Germany Localized Recrudescence of Toxoplasma Gondii* Infections in the central nervous system of Immunocompromised mice Assessed by In Vivo Bioluminescence imaging** Dellacasa-Lindberg, Isabel [] , Hitziger, Niclas , Barragan, Antonio Karolinska Institute and Swedish Institute for Infectious Disease Control, Stockholm, Sweden Luciferase Based High Throughput Screening of P. falciparum* Darling, Claire , Greenbaum , Doron [] Pharmacology, University of Pennsylvania, Philadelphia , PA, USA* M Malaria Pathogenesis: Deformability Limits of Infected Erythrocytes Herricks, Thurston E, Antia, Meher , Rathod, Pradipsinh K [] Chemistry, University of Washington, Seattle, WA, USA Mapping selective pressure in highly divergent parasite genomes* Caspi, Anat [] , Roos, David Biology, University of Pennsylvania, Philadelphia, PA, USA Membrane proteins of the Toxoplasma* apicoplast** DeRocher, Amy E [,1] , Karnataki, Anuradha [1] , Coppens, Isabelle [2] , Bradley, Peter [3] , Gilbert, Luke [3] , Feagin, Jean E [1] , Parsons, Marilyn [1] 1. Seattle Biomedical Research Institute, Seattle, WA, USA 2. Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA 3. Microbiology, Immunology and Molecular Genetics, Universtiy of California Los Angeles, Los Angeles, CA, USA Microarray Analysis of Bradyzoite Differentiation in Toxoplasma gondii* Bahl, Amit [,1] , Davis, Paul H [2] , Dzierszinski, Florence [3] , Behnke, Michael [4] , White, Michael [4] , Roos, David S [2] 1. Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA 2. Biology, University of Pennsylvania, Philadelphia, PA, USA 3. Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, Canada 4. Montana State University, Bozeman, USA miRNA-mediated translational repression in Giardia lamblia* Saraiya, Ashesh A, Wang, C C [] UCSF, San Francisco, CA, USA Mitochondrial ATPase activity in intraerythrocytic malaria parasites* Mather, Michael W [] , Morrisey, Joanne M, Balabaskaran Nina, Praveen , Vaidya, Akhil B Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Modulation of Host Immunity To Leishmania by Vector Sand Flies* Sacks, David [] , Peters, Nathan , Kimblin, Nicola , Egen, Jackson , Germain, Ron , Debrabant, Alain , Lawyer, Phillip , Secundino, Nagila NIAID, NIH, Bethesda , us MOLECULAR MECHANISMS UNDERLYING ERYTHROCYTE INVASION IN HUMAN BABESIOSIS* Montero, Estrella [,1] , Gonzalez, Luis M [2] , Rodriguez, Marilis [1] , Blackman, Michael J [3] , Lobo, Cheryl A [1] 1. Blood Borne Parasites, LFKRI New York Blood Center, New York, NY, EEUU 2. Parasitology, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain 3. Division of Parasitology, National Institute For Medical Research, London, United Kingdom Motility during the Toxoplasma gondii* lytic cycle** Arrizabalaga, Gustavo [] University of Idaho, Moscow, United States mRNA Granules in Trypanosomes* Cassola, Alejandro , De Gaudenzi, Javier G, Frasch, Alberto C [] Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico Chascomús, UNSAM-CONICET, Buenos Aires, Argentina Mutagenesis of Plasmodium* genes expressed in pre-erythrocytic stages** Boisson, Bertrand [1] , Bischoff, Emmanuel [2] , Chertemps, Thomas [3] , Lacroix, Céline [1] , Thiberge, Sabine [1] , Ménard, Robert [1] , Rosinski-Chupin, Isabelle [1] , baldacci, patricia [,1] 1. Parasitology and Mycology, Institut Pasteur, Paris, France 2. Genome and Genetics, Institut Pasteur, Paris, france 3. Parasitology and Mycology, Institut Pasteur, Paris, france N N-glycosylation of proteins in Toxoplasma gondii* Luk, Flora [] , Johnson, Terezina , Beckers, Con Cell & Developmental Biology, UNC-Chapel Hill, Chapel Hill, NC, USA Novel Anti-Malarial Discovery and the Fruits of Our Bountiful Seas* Prudhomme, Jacques G [1] , McDaniel, Eric [1] , Ponts, Nadia [1] , Jensen, Paul [2] , Fenical, William [2] , Kubanek, Julia [3] , Hay, Mark [4] , Le Roch, Karine G [,1] 1. Cell Biology & Neuroscience, University of California, Riverside, Riverside, CA, USA 2. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA 3. School of Biology and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA 4. School of Biology, Georgia Institute of Technology, Atlanta, GA, USA N-terminal Processing of Proteins Exported by Malaria Parasites* Chang, Henry H [,1] , Falick, Arnold M. [2] , Carlton, Pete [3] , Sedat, John W. [3] , DeRisi, Joseph L. [3] , Marletta, Michael A. [1] 1. Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA 2. Howard Hughes Medical Institute Mass Spetrometry Laboratory, University of California, Berkeley, Berkeley, CA, USA 3. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA O Optimization of piggyBac-mediated mutagenesis of* Plasmodium falciparum Balu, Bharath [,1] , Maher, Steven P [2] , Shoue, Douglas A [2] , White, Ben R [2] , Wisler, Bradley A [2] , Xue, Yi [2] , Kissinger, Jessica [3] , Adams, John H [1] 1. Global Health, University of South Florida, College of Public Health, Tampa, FL, USA 2. Biological Sciences, University of Notre Dame, Notre Dame, IN, USA 3. Department of Genetics, University of Georgia, Athens, GA, USA P Persistent cytoadherence of drug treated Plasmodium falciparum* infected red blood cells** Hughes, Katie R [] , Biagini, Giancarlo , Craig, Alister Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK PfVP2, a proton-pumping pyrophosphatase, is not essential in blood stages of P. falciparum* Morrisey, Joanne M [,1] , McIntosh, Michael T. [2] , Mather, Michael W. [1] , Vaidya, Akhil B. [1] 1. Micro/Imm, Drexel Univ. college of Med., Philadelphia, PA, USA 2. Department of Medicine, Yale Univ. School of Medicine, New haven, CT, USA Phenotypic characterization of a P. berghei* K⁺ channel knock-out parasite (Äpbkch1)** Ellekvist, Peter [,1] , Maciel, Jorge [2] , Mlambo, Godfree [2] , Klaerke, Dan [3] , Kumar, Nirbhay [2] 1. Cellular and Molecular Medicine, Faculty of Health Sciences, University of Cph, Copenhagen, Denmark 2. Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 3. Physiology and Biochemistry, Faculty of Life Sciences, University of Cph, Copenhagen, Denmark Phosphatidylinositol 3-Phosphate in Plasmodium* blood stage development** Tawk, Lina [,1] , Payrastre, Bernard [2] , Vial, Henri [1] , Roy, Christian [1] , Wengelnik, Kai [,1] 1. Université Montpellier II-CNRS- UMR5235, Montpellier, France 2. Oncogenèse, Signalisation et Innovation thérapeutique, Inserm U563 BAT B CHU Purpan, Toulouse cedex 3, France Phosphorylation profile analysis during nutritional stress in Trypanosoma cruzi Ferreira, Ludmila R.P., Chung, Janete , Schenkman, Sergio [] Microbiology Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil Photosynthetic alveolate RM12 shares common origin with apicomplexan parasites* Obornik, Miroslav [,1] , Janouskovec, Jan [1] , Chrudimsky, Tomas [1] , Vancova, Marie [2] , Wright, Simon [3] , Moore, Robert [4] , Carter, Dee 1. Molecular biology of protists, Biology Centre ASCR, Institute of Parasitology, Ceske Budejovice, Czech Republic 2. Institute of Parasitology, Ceske Budejovice, Czech Republic 3. Australian Antarctic Division, Kingston, Australia 4. University of Sydney, Sydney, Australia Plasmepsin X is important for Plasmodium* Invasion of its Mosquito Vector** Bounkeua, Viengngeun [] , Li, Fengwu , Vinetz, Joseph Medicine, University of California, San Diego, La Jolla, CA, USA Plasmodium falciparum histone deacetylases as antimalarial targets* Tran, Thanh Nguyen [,1] , Lucke, A. J [2] , Kahnberg , P , Le, G. T , Boyle, G. M [3] , Gardiner, D. L [4] , Skinner-Adams, T. S [5] , Fairlie, D. P , Andrews, K. T [6] 1. Immunology and Infectious Diseases, QLD institute of Medical Research, Brisbane, Australia 2. University of Queensland, Brisbane, Australia 3. Population and Clinical Sciences, QLD institute of Medical Research, Brisbane, Australia 4. Immunology and Infectious Diseases, QLD institute of Medical Research, Brisbane, Australia 5. School of Medicine, University of Queensland, Brisbane, Australia 6. Immunology and Infectious Diseases, QLD institute of Medical Research, Brisbane, Australia Plasmodium falciparum* Infected Erythrocytes Induces Hypoxia like Global Gene Expression in Cerebral Endothelial Cells Tripathi, Abhai K [,1] , Stins, Monique F [2] , Sullivan, David J [1] 1. Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, USA 2. Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA Plasmodium falciparum* Pf34, a Novel GPI-anchored Rhoptry Protein found in Detergent Resistant Microdomains Proellocks, Nicholas I [1] , Kovacevic, Svetozar [1] , Ferguson, David J.P. [2] , Kats, Lev M [1] , Morahan, Belinda J [1] , Black, Casilda G [1] , Waller, Karena L [1] , Coppel, Ross L [,1] 1. Microbiology, Monash University, Melbourne, Australia 2. Nuffield Department of Pathology, Oxford University, Oxford, United Kingdom Plasmodium falciparum* Reticulocyte Homology Protein 4 (RH4) binds to the erythrocyte surface and mediates erythrocyte invasion through the sialic acid independent pathway Gaur, Deepak , Singh, Sanjay , Jiang, Lu-bin , Zhou, Hong , Diouf, Ababacar , Long, Carole , Miller, Louis [] Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, MD, USA Plasmodium falciparum* Sec22p Homologue Forms a SNARE Complex with PfBet1p, PfGS27p, and PfSyn5p and Targets to the PVM and Extra-parasitic Compartments Ayong, Lawrence [1] , Lee, Marcus [2] , Barrero-Tobon, Angelica [1] , Fidock, David [2] , Chakrabarti, Debopam [,1] 1. Molecular Biology & Microbiology, University of Central Florida, ORLANDO, FL, USA 2. Microbiology, Columbia University, New York, NY, USA Plasmodium falciparum* Serine Hydroxymethyltransferase: Binding of Substrate, Inhibitor, and Cognate RNA Pang, Cullen K.T., Rathod, Pradipsinh K [] Chemistry, University of Washington, Seattle, USA Plasmodium Ins and Outs: Merozoite Proteomics and Informed Gene Disruption* Khan, Shahid M [,1] , van Dijk, Melissa [1] , Franke-Fayard, Blandine [1] , Lasonder, Edwin [2] , Berry, Andrew [3] , van Dooren, Maaike [1] , Kocken, Clemens [4] , Boehme, Ulrike [3] , Grainger, Muni [5] , Stunnenberg, Henk [2] , Pain, Arnab [3] , Berriman, Matthew [3] , Holder, Anthony [5] , Thomas, Alan [4] , Mann, Matthias [6] , Janse, Chris [1] , Waters, Andrew [1] 1. Parasitology, Leiden University Medical Centre, Leiden, Netherlands 2. Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands 3. The Welcome Trust Sanger Institute, Cambridge, UK 4. Biomedical Primate Research Centre, Rijswijk, Netherlands 5. National Institute for Medical Research, London, UK 6. University of Southern Denmark, Odense, Denmark Plasmodium* sporozoite interactions with host cell membrane during migration versus invasion Bennett, Brandy Lee [,1] , Coppi, Alida [1] , Sato, Satoshi B [2] , Murray, John M [3] , Sinnis, Photini [1] 1. Molecular Parasitology, NYU School of Medicine, NY, NY, USA 2. Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan 3. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA Plasmodium vivax* DBP binding to Aotus nancymai erythrocytes is Duffy dependent McHenry, Amy M [1] , Barnwell, John W [2] , Adams, John H [,3] 1. Biological Sciences, University of Notre Dame, Notre Dame, IN, USA 2. Division of Parasitic Diseases, Centers For Disease Control & Prevention, NE Atlanta , GA, USA 3. Global Health, University of South Florida, College of Public Health, Tampa, FL, USA Polyadenylation Stabilizes Translationally-competent mRNAs in Trypanosome Mitochondria* Etheridge, Ronald Drew [] , Aphasizheva, Inna , Aphasizhev, Ruslan Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA Poly[dT-dG].[dC-dA] signals in Trypanosoma cruzi* genome** Duhagon, María A [1] , Smircich, Pablo [1] , Pastro, Lucía [1] , Pérez-Díaz, Leticia [1] , Sotelo-Silveira, José R [2] , Maugeri, Dante [3] , Dallagiovanna, Bruno [4] , Williams, Noreen [5] , Garat, Beatriz [,1] 1. Facultad de Ciencias, Montevideo, Uruguay 2. Facultad de Ciencias/IIBCE, Montevideo, Uruguay 3. Universidad Nacional de General San Martin, Buenos Aires, Argentina 4. Instituto de Biologia Molecular do Parana, Curitiba, Brazil 5. University at Buffalo, Buffalo, NY, USA Positive selection for Asn-linked glycosylation in eukaryotes with N-glycan-associated quality control of protein folding* Cui, Jike [1] , Smith, Temple [2] , Robbins, Phillips [1] , Samuelson, John [,1] 1. Molecular and Cell Biology, Boston University, Boston, MA, USA 2. Biomedical Engineering, Boston University, Boston, MA, USA Pre-mRNA splicing in Plasmodium falciparum* Zhang, Xiaohong [1] , Gallagher, Ryan [1] , Haas, Brian J. [2] , Gardner, Malcolm J. [1] , Feagin, Jean E. [,1] 1. Seattle Biomedical Research Institute, Seattle, WA, USA 2. J. Craig Venter Institute, Rockville, MD, USA Processing of Plasmodium yoelii-infected erythrocytes after phagocytosis by dendritic cells and macrophages* Bettiol, Esther , Rodriguez, Ana [] Department of Medical Parasitology, NYU School of Medicine, New York, NY, USA Protein phosphatase 5 modulates Hsp90 function during proteotoxic stresses in Trypanosoma brucei* Singha, Ujjal K [1] , Jones, Candace [1] , Anderson, Sedrick [2] , Chaudhuri, Minu [,1] 1. Microbiology, Meharry Medical College, Nashville, TN, USA 2. Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA Protein-protein Interactions of P. falciparum* Merozoite Invasion Machinery** Hu, Guangan , Bozdech, Zbynek [] School of biological sciences, Nanyang Technological University, Singapore, Singapore Proteolytic Processing of the Circumsporozoite Protein Occurs within the Highly Conserved Region I and is Required for Efficient Invasion of Hepatocytes by Plasmodium* Sporozoite** Coppi, Alida [] , Natarajan, Ramya , Sinnis, Photini Medical Parasitology, NYU School of Medicine, New York, NY, USA Proteolytic Processing of TRAP by Plasmodium* Sporozoites** Ejigiri, Ijeoma L, Kwakye , Kwadjo , Sinnis, Photini [] Medical Parasitology, NYU School of Medicine, New York , NY, USA Proteome and transcriptome changes in the parasite Giardia intestinalis* upon interaction with human intestinal epithelial cells** Ringqvist, Emma [,1] , Skarin, Hanna [1] , Palm, Daniel J E [1] , Hellman, Ulf [2] , Svärd, Staffan G [1] 1. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden 2. Ludwig Institute for Cancer Research, Uppsala, Sweden Proteome characterization and discovery of novel protein families in apicomplexa using comparative analyses* Date, Shailesh V, Pinney, Deborah F, Stoeckert, Christian J [] Genetics, University of Pennsylvania, Philadelphia, PA, USA Proteomic analysis of acidocalcisomes from Trypanosoma cruzi* and T. brucei reveals the expression of novel enzymes and transporters** Ulrich, Paul N [1] , Fang, Jianmin [1] , Atwood, James [2] , Orlando, Ron [2] , Tarleton, Rick [1] , Moreno, Silvia N. J. [1] , Docampo, Roberto [,1] 1. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA 2. Complex Carbohydrate Research Center, University of Gerogia, Athens, GA, USA PROTEOMICS OF TOXOPLASMA GONDII* Xia, Dong [1] , Sanderson, Sanya J [1] , Prieto, Helena [2] , Wastling, Jonathan M [,1] 1. Pre-clinic Veterinary Science, University of Liverpool, Liverpool, UK 2. Department of Cell Biology (I.X.M., J.R.Y.), The Scripps Institute, La Jolla, CA, USA Proteophosphoglycan confers Leishmania* resistance to midgut digestive enzymes induced by blood feeding in vector sand flies** Secundino, Nagila F [1] , Kimblin, Nicola [1] , Lawyer, Phillip [1] , Beverley, Stephen [2] , Turco, Sam [3] , Sacks, David [,1] 1. NIAID, NIH, Bethesda, MD, US 2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, us 3. Department of Biochemistry, , University of Kentucky Medical Center, Lexington, KY, us Q Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin* Kuhn, Yvonne , Rohrbach, Petra , Lanzer, Michael [] Hygiene Institute, Heidelberg, Germany R Rab1 GTPase is crucial for development of cysts in Giardia lamblia morf, laura [,1] , Kulangara, Caroline [2] , Regös, Attila [3] , Stefanic, Sasa [1] , Sonda, Sabrina [1] , Hehl, Adrian B. [1] 1. Cell biology, University of Zurich, zurich, Switzerland 2. Swiss Tropical Institute, Basel, Switzerland 3. University of Melbourne, Melbourne, Australia Rapid and efficient in vitro excystation of Entamoeba invadens Mitra, Biswa Nath [1] , Pradel, Gabriele [2] , Eichinger, Daniel [,1] 1. Medical Parasitology, New York University School of Medicine, New York, NY, USA 2. Zentrum fuer Infektionsforschung, University of Wuerzburg, Wuerzburg, Germany Reconstitution of Trypanosome Lytic Factors in Transgenic Mice Reveals Broad Antiparasitic Activity* Samanovic, Marie [1] , Molina-portela, Pilar [1] , Chessler, Anne [2] , Burliegh, Barbara [2] , Raper, Jayne [,1] 1. medical parasitology, nyu School of Medicine, new York, NY, uSA 2. immunology and infectious disease, harvard school of public health, boston, MA, usa Regulated Export of Cyst Wall Material in Giardia: Selective Condensation vs. Dynamic Mobility of Cargo* Hehl, Adrian B. [] , Stefanic, Sasa Institute of Parasitology, University of Zürich, Zürich, Switzerland Regulated telomeric DNA glycosylation by two thymine hydroxylase enzymes in Trypanosoma brucei* Birkeland, Shanda R., Cliffe, Laura J., Kieft, Rudo , Sabatini, Robert [] Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States Regulation of gMyb2 by Cyclin-Dependent Kinases in Giardia lamblia* Huang, Yu-Chang , Su, Li-Hsin , Sun, Chin-Hung [] Department of Parasitology, College of Medicine, National Taiwan University, Taipei, Taiwan Regulation of gMyb2 by Cyclin-Dependent Kinases in Giardia lamblia* Huang, Yu-Chang , Li-Hsin, Su , Chin-Hung, Sun [] Department of Parasitology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China Regulation of Plasmodium falciparum Calcium Dependent Protein kinase 4 (PfCDPK4)* Ranjan, Ravikant [] , Sharma, Pushkar National Instt. of Immunology, India, New Delhi, India Regulation of repeat stability and homologous recombination by glycosylated DNA in Trypanosoma brucei* Southern, Timothy [1] , Cliffe, Laura [1] , Kieft, Rudo [2] , Sabatini, Robert [,1] 1. Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA 2. Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA Regulation of temporal and iron-inducible transcription by differential and alternate promoter entry of multiple Myb proteins in Trichomonas vaginalis* Tai, Jung-Hsiang [,1] , Ong, Shiou-Jeng [2] , Hsu, Hong-Ming [1] , Liu, Hsing-Wei [1] 1. Infectious Diseases, Institute of Biomedical Sciences, Taipei, Taiwan 2. Graduate Institute of Microbiology, National Taiwan University, Medical School, Taipei, Taiwan Regulatory pathways controlling erythrocyte invasion by Plasmodium falciparum* Jones, Matthew L, Rayner, Julian C [] Medicine and Cell Biology, University of Alabama at Birmingham, Birmingham, United States Rhoptry Neck Proteins in the Moving Junction of Toxoplasma gondii: the keys to filtration?* Straub, Kurtis W., Cheng, Stephen J. Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States of America RNA interference machineries in trypanosomatid protozoa Ullu, Elisabetta [,1] , Beverley, Stephen M. [2] , Lye, Lon-Fye [2] , Owens, Katherine [2] , Shi, Huafang [1] , Tschudi, Christian [3] 1. Internal Medicine, Yale University, New Haven, CT, USA 2. Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA 3. Epidemiology and Public Health, Yale University, New Haven, CT, USA RNAi is alive and well in Leishmania braziliensis* Lye, Lon-Fye (George) [1] , Owens, Katherine [1] , Shi, Huafang [2] , Tschudi, Christian [2] , Ullu, Elisabetta [2] , Beverley , Stephen M [,1] 1. Molecular Microbiology, Washington University, St.Louis, MO, USA 2. Internal Medicine, Yale School of Medicine, New Haven, CT, USA RNAi-based structure-function analysis of the flagellar protein trypanin in Trypanosoma brucei* Ralston, Katherine S, Shaffer, Hope E, Hill, Kent L [] Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA Role of CXXC Plasma Membrane Proteins in Entamoeba histolytica* virulence** Linford, Alicia S [,1] , Boettner, Douglas R. [1] , Petri, William A. [,2] 1. Infectious Diseases, University of Virginia, Charlottesville, VA, USA 2. Microbiology, Medicine, and Pathology, University of Virginia, Charlottesville, VA, USA Role of PfTBP in stage specific gene regulation in the human malarial parasite (I) P. falciparum (/I) Gopalakrishnan, Anusha M [] , Lopez-Estrano, Carlos Biology, University of Memphis, memphis, TN, US Role of the cell traversal activity of the malaria sporozoite* Giovannini, Donatella [1] , Amino, Rogerio [1] , Thiberge, Sabine [1] , Gueirard, Pascale [1] , Dubremetz, Jean Francois [2] , Prevost, Marie Christine [3] , Ishino, Tomoko [4] , Yuda, Masao [4] , Ménard, Robert [,1] 1. Biologie et Génétique du Paludisme, Institut Pasteur, Paris, France 2. University of Montpellier, Montpellier, France 3. Institut Pasteur, Paris, France 4. Mie University, Mie, Japan Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum* Dalal, Seema , Bompiani, Kristin , Klemba, Michael [] Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States S Screening herbicides targeting plant chloroplast MGDG synthesis to develop new antiplasmodials* Saïdani, Nadia [,1] , Botté, Cyrille [2] , Bonneau, Anne-Laure [3] , Deligny, Michael [3] , Rousseau, Bernard [3] , Dubremetz, Jean-François [4] , Vial, Henri [4] , Lopez, Roman [3] , Maréchal, Eric [1] 1. iRTSV, CEA, Grenoble, France 2. Institut Jean Roget, La Tronche, France 3. CEA, Saclay, France 4. Université Montpellier II, Montpellier, France Sex and stage-specific reporter gene expression in Plasmodium falciparum* Eksi, Saliha , Williamson, Kim C [] Loyola University Chicago, Chicago, USA siRNA Screen of Human Kinases, Phosphatases and G-proteins for Toxoplasma gondii* Growth Sweeney, Kristin R, Blader, Ira Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Small molecule inhibition of Plasmodium falciparum Sir2** Merrick, Catherine J [1] , Taveras, Kennedy M [2] , Lewis, Timothy A [2] , Koehler, Angela N [2] , Duraisingh, Manoj T [,1] 1. Immunology and Infectious Disease, Harvard School of Public Health, Boston, USA 2. Broad institute of Harvard and MIT, Cambridge, MA, USA Small Molecule Inhibitors of the P. falciparum* MyoA Tail-MTIP Interaction** Bergman, Lawrence W [,1] , Kortagere, Sandhya [2] , Morrisey, Joanne [3] , Bosch, Juergen [4] , Daly, Thomas [1] , Welsh, William [2] , Hol, Wim [4] , Ejigiri, Ijeoma [5] , Sinnis, Photini [5] , Vaidya, Akhil [1] 1. Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, PA, USA 2. Pharmacology, UMDNJ_RWJMS, Piscataway, NJ, USA 3. Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, PA, USA 4. Biochemistry & Biological Structure, University of Washington, Seattle, WA, USA 5. Molecular Parasitology, New York University School of Medicine, New York, NY, USA snRNA of Plasmodium falciparum* Bawankar, Praveen , Patankar, Swati [] Biotechnology, Indian Institute of Technology Bombay Powai Mumbai , Mumbai, India Sphingolipid Metabolic Genes are Important for Endocytosis and Cyst Wall Biogenesis in an Intestinal Protozoan, Giardia lamblia* Mendez, Tavis Lyle, Hernandez, Yunuen V, Duarte, Trevor T, Das, Siddhartha [] Biological Sciences, University of Texas at El Paso, El Paso, USA Spinning Disk Confocal Microscopic Studies of the Stage Dependence of Chloroquine Toxicity* Gligorijevic, Bojana [1] , Purdy, Kyle [1] , Urbach, Jeffrey [2] , Roepe, Paul David [,1] 1. Biochemistry, Cell. & Mol. Biol. , Georgetown, Washington, DC, USA 2. Physics, Georgetown University, Washington, DC, USA Stable expression of a GFP-BSD fusion protein in transfected and blasticidin-selected Babesia bovis* merozoites** Suarez, Carlos E. [,1] , McElwain, Terry F. [2] 1. ARS, USDA, Pullman, WA, USA 2. Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA Structural analysis of the MAEBL ligand domains* Mendonca, Sarita [] , Adams, John H Global Health, University of South Florida, College of Public Health, Tampa, FL, USA Structure-function analysis of xanthurenic acid as activator of gametogenesis in Plasmodium* Bex, Claudia [] , Billker, Oliver Imperial College, London, UK Structures of Trypanosoma brucei* Pex5 bound to Peroxisomal Targeting Signal 1 peptides: clues for anti-trypanosomatid drug design** Sampathkumar, Parthasarathy [1] , Roach, Claudia [1] , Michels, Paul A.M. [2] , Hol, Wim G.J. [,1] 1. Department of Biochemistry, University of Washington, Seattle, WA, USA 2. Research Unit for Tropical Diseases, Universite catholique de Louvain, Brussels, Belgium Subtilisin-like proteases of Cryptosporidium parvum* Wanyiri, Jane W [1] , OConnor, Roberta [1] , Blackman, Michael [2] , Kim, Kami [3] , Ward, Honorine [,1] 1. Tufts-New England Medical Center, Boston, MA, USA 2. The National Institute for Medical Research, London, UK 3. Albert Einstein College of Medicine, NY , NY, USA Systemic immune response of mice to mucosal immunisation with a heterologous protein expressed on lactic acid bacteria* Moorthy, Sivagowry A. V. [,1] , Ramasamy, Ranjan - [2] 1. Biotechnology, National Science Foundation, Colombo 07 , Sri Lanka 2. Institute of Medicine, University of Brunei, Jalan Tungku Link, Gadong BE 1410, BRUNEI DARUSSALAM T Targeting the Minimalist Mitochondrion of Malaria Parasites* Vaidya, Akhil B [] Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA The Adaptor Protein 1 (AP1) Complex Plays a Key Role in the Trafficking of Lysosomal Proteins in Procyclic Trypanosomes* Tazeh, Ngii N [1] , Bangs, James D [,2] 1. Biomolecular Chemistry, UW-Madison, Madison, WI, USA 2. Medical Microbiology and Immunology, UW-Madison, Madison, WI, USA THE CARBON DIOXIDE SENSOR OF PLASMODIUM FALCIPARUM* AS A TARGET FOR KILLING MALARIA PARASITES** Bank, Erin M [1] , Deitsch, Kirk W [2] , Hess, Kenneth C [1] , Buck, Jochen [,1] , Levin, Lonny R [1] 1. Pharmacology, Weill Cornell Medical College, New York, NY, USA 2. Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA T The complete set of SNARE proteins that mediate membrane fusion events in Giardia lamblia* Elias, Eliana Vanina [] , Quiroga, Rodrigo [] , Lujan, Hugo Daniel [] IMMF-INIMEC-CONICET and Universidad Catolica de Cordoba, Cordoba, Argentina The conserved structure of the CIDR domain of PfEMP1* Klein, Michael [1] , Gittis, Apostolos [1] , Su, Hua-Poo [1] , Makobongo, Morris [2] , Moore, Jaime [1] , Singh, Sanjay [2] , Miller, Louis [2] , Garboczi, David [,1] 1. NIAID, Rockville, MD, US 2. NIAID, NIH, Rockville, MD, US THE FUNCTIONAL ROLE OF CK2 (CASEIN KINASE II) IN PLASMODIUM FALCIPARUM* Holland, Zoe J, Reininger, Luc , Doerig, Christian [] Wellcome Centre for Molecular Parasitology, Glasgow University, Glasgow, UK The glutathione detoxification pathway is essential for mosquito stage development in Plasmodium berghei.* Vega-Rodriguez, Joel [1] , Dinglasan, Rhoel R [2] , Franke-Fayard, Blandine [3] , Pastrana-Mena, Rebecca [1] , Gerena, Yamil [1] , Rodríguez-Orengo, José [4] , Delgado-Morales, Wilfredo [4] , Jacobs-Lorena, Marcelo [2] , Waters, Andrew P [3] , Janse, Chris J [3] , Serrano, Adelfa E [,1] 1. Microbiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico 2. Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA 3. Parasitology, Leiden University Medical Center, Leiden, The Netherlands 4. Biochemistry, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico The Histone Acetytransferase PfMYST in Plasmodium falciparum* Miao, Jun , Qi, Fan , Cui, Long , Cui, Liwang [] Penn State University, Univeristy Park, PA, USA The Histone Acetytransferase PfMYST in Plasmodium falciparum* The LAMP-like Protein p67 Plays an Essential Role in the Lysosome of African Trypanosomes Peck, Ronald F [1] , Shiflett, April M [2] , Tazeh, Ngii N [1] , Hajduk, Stephen L [2] , Bangs, James D [,1] 1. Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, USA 2. Biochemistry and Molecular Biology, Uniersity of Georgia, Athens, GA, USA The Leishmania infantum* SIR2 deacetylase induces B-lymphocyte activation and proliferation and signals via a Toll-Like receptor 2** Silvestre, Ricardo [,1] , Cordeiro-da-Silva, Anabela [2] , Ouaissi, Ali [1] 1. IRD, Montpellier, France 2. IBMC, Porto, Portugal The Mechanism of Serum Resistance Associated Protein Inhibition of Trypanosome Lytic Factor (TLF) may Involve Lysosomal Degradation* Stephens, Natalie A., Shiflett, April M., Hajduk, Stephen L. [] Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA The molecular mechanism of immune recognition of Toxoplasma gondii* by CD8+ T cells** Frickel, Eva M [1] , Grotenbreg, Gijsbert M [1] , Wuethrich, Irene [1] , Van der Veen, Annemarthe [1] , Hopp, Jonathan [2] , Gubbels, Marc-Jan [2] , Ploegh, Hidde [,1] 1. Whitehead Institute, Cambridge, MA, USA 2. Biology, Boston College, Chestnut Hill, MA, USA The Plasmodium falciparum* Rhoptry associated protein 1 is escorted to the rhoptries by the Rhoptry associated membrane antigen** Richard, Dave [,1] , Kats, Lev M [2] , Coppel, Ross L. [2] , Cowman, Alan F. [1] 1. Infection and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia 2. Microbiology, Monash University, Clayton, Australia The role of ATP synthase subunit 9 in the maintenance of procyclic Trypanosoma brucei* mitochondrial membrane potential and ATP synthase subunit regulation Gulde, Paul E, Brown, Silvia V, Williams, Noreen Microbiology and Immunology, University at Buffalo, SUNY, Buffalo, NY, USA The role of CD81 in the interaction of Plasmodium yoelii with hepatocyte organelles** Mwakingwe, Agnes [1] , Levy, Shoshana [2] , Sinnis, Photini [3] , Dragic, Tatiana [1] , Kim, Kami [,1] 1. Dept. of Medicine, Dept. of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA 2. Division of Oncology , Stanford University, Stanford, CA, USA 3. Medical Parasitology, New York University School of Medicine, New York, NY, USA The tetrameric [LDH-like] malate dehydrogenase of Plasmodium falciparum* is an evolutionary adaptation for cytosolic energy requirements** Pradhan, Anupam [,1] , Mukherjee, Prasenjit [2] , Tripathi, Abhai K [3] , Avery, Mitchell A. [2] , Walker, Larry A [1] , Tekwani, Babu L [1] 1. School of Pharmacy, University of Mississippi, University, MS, United States 2. School of Pharmacy, University of Mississippi, University, MS, United States 3. John Hopkins University, Baltimore, MD, United States The Toxoplasma gondii* apicoplast shows pronounced intracellular movement** Jordan, Carly N [] , Striepen, Boris Department of Cellular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA The Toxoplasma gondii* kinome reveals a coccidian specific family of kinases that are secreted via the rhoptries** Peixoto, Lucia , Chen, Feng , Harb, Omar , Bahl, Amit , Davis, Paul H, Roos, David S [] Biology and Penn Genomics Institute, University of Pennsylvania, Philadelphia, PA, USA The ubiquitin-proteasome system and the erythrocytic cell cycle progression of the human malaria parasite, Plasmodium falciparum* Ponts, Nadia P [1] , Yang, Jianfeng [1] , Girke, Thomas [2] , Prudhomme, Jacques [1] , Horrocks, Paul [3] , Le Roch, Karine [,1] 1. Cell Biology and Neurosciences, University of California at Riverside, Riverside, CA, USA 2. University of California at Riverside, Riverside, CA, USA 3. Departments of Medecine and Life Sciences, Keele University, Keele, United Kingdom The Unexpected Nature of Antisense Transcripts in Giardia* Teodorovic, Smilja [1] , Bardonova, Lucie [2] , Bregy, Patrick [2] , Canepa, Gaspar [2] , Franta, Zdenek [2] , Ghosh, Kaya [2] , Henrich, Philipp [2] , Israelsson, Elisabeth [2] , Tait, Elia [2] , Elmendorf, Heidi G [,1] 1. Biology, Georgetown University, Washington, DC, USA 2. Marine Biological Laboratories, Woods Hole, MA, USA Tissue invasion by Entamoeba histolytica: Evidence of genetic selection and / or DNA reorganization events in organ tropism* Ali, Ibne Karim M. [1] , Solaymani-Mohammadi, Shahram [1] , Roy, Shantanu [2] , Gorrini, Chiara [3] , Calderaro, Adriana [3] , Parker, Sarah K [4] , Haque, Rashidul [2] , Petri, Jr, William A [,1] , Clark, C. Graham [,5] 1. Infectious Diseases, University of Virginia, Charlottesville, VA, USA 2. International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh 3. Section of Microbiology, University of Parma, Parma, Italy 4. Division of Infectious Diseases, University of Colorado, Denver, CO, USA 5. London School of Hygiene & Tropical Medicine, London, GB *To Live or Let Die: Determining the Role of Plasmodium falciparum* Mitochondria in the Face of Electron Transport Inhibition** Painter, Heather J, Morrisey, Joanne M, Vaidya, Akhil B [] Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Tonicity-Dependent Detachment of Giardia lamblia* Hansen, Wendy R. [,1] , Fletcher, Daniel A. [2] 1. Biophysics Graduate Group/Bioengineering Dept., UC Berkeley, Berkeley, USA 2. Bioengineering, UC Berkeley, Berkeley, CA, USA Toxolysin: a Novel Member of the Insulysin Family* Hajagos, Bettina [,1] , Lebrun, Maryse [2] , Dubremetz, Jean François [2] , Bradley, Peter [1] 1. MIMG, UCLA, Los Angeles, CA, United States 2. Université de Montpellier 2, Montpellier, France Toxoplasma gondii* PhIL1 is involved in parasite growth and morphology Dotzler, Whittney C. [,1] , Gilk, Stacey [2] , Ward, Gary E. [1] 1. Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, USA 2. Cell and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Toxoplasma gondii rhoptry discharge induces host EGR* Blader, Ira [] , Phelps, Eric Microbiology and Immunology, OUHSC, Oklahoma City, OK, USA Tracing the origin, molecular identity and genetic diversity of the Plasmodium falciparum* FCR3/Gambia family** Rajapandi, Thavamani [,1] , Mu, Jianbing [2] , Su, Xinzhuan [2] , Stedman, Timothy 1. MR4, ATCC, Manassas, VA, USA 2. LMVR, NIAID, NIH, Bethesda, MD, USA Translational Regulation of var2csa, a Gene Implicated in Placental Sequestration of Malaria Parasites* Amulic, Borko [1] , Salanti, Ali [2] , Deitsch, Kirk W [,1] 1. Microbiology and Immunology, Weill Medical College of Cornell university, New York, NY, USA 2. Centre for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital, Copenhagen, Denmark Trichomonas vaginalis: Iron-dependent changes of gene expression studied by microarrays analysis Tachezy, Jan [,1] , Basler, Marek [2] , Horvathova, Lenka [1] , Tang, Petrus [3] , Shin, J.W. [4] , Bardonova, Lucie [1] 1. Charles University, Prague, Czech Republic 2. Academy of Science of the Czech Republic, Prague, Czech Republic 3. Chang Gung University, Taoyuan, Taiwan 4. National Cheng Kung University, Tainan, Taiwan Two RNA-binding proteins involved in ribosome biogenesis in Trypanosoma brucei Ciganda, Martin , Hellman, Kristina , Brown, Silvia , Li, Jinlei , Ruyechan, William , Williams, Noreen [] Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA U UNEXPECTED METABOLIC PATHWAYS IN THE MITOCHONDRION OF TOXOPLASMA GONDII* Limenitakis, Julien [1] , Fleige, Tobias [1] , Foth, Bernardo [2] , Soldati, Dominique [,1] 1. Departement of microbiology and molecular medicine Faculty of Medicine, University of Geneva, Geneva, Switzerland 2. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore Unidentified Plasmodium Infection in the Australian Black Swan Sullivan, Margery [,1] , Grim, K. Christiana [1] , Cranfield, Mike R. [2] , McCutchan, Thomas F. [1] 1. LMVR, NIAID, NIH, Rockville, USA 2. Druid Hill, Baltimore , MD, USA Unique proteins and carbohydrates of oocyst walls and sporozoites of Cryptosporidium parvum Chatterjee, Anirban [1] , Banerjee, Sulagna [1] , Magnelli, Paula [1] , Steffen, Martin [2] , Robbins, Phillips W [1] , Samuelson, John C [,1] 1. Molecular and Cell Biology, Boston University, Boston, MA, USA 2. Genetics and Genomics Department, Boston University, Boston, MA, USA Unravelling The Trafficking Determinants Of Toxoplasma gondii* Rhomboid-Like Proteins** Sheiner, Lilach Betty [] , Dowse, Timothy James, Soldati, Dominique MIMOL, CMU, university of Geneva, Geneva, Switzerland Using denaturing HPLC to Genotype P. falciparum Genes- Application to the Vaccine Candidate PfMSP3* Jordan, Stephen , Crowley, Michael , Branch, OraLee , Rayner, Julian [] Medicine, University of Alabama at Birmingham, Birmingham, AL, United States Utilizing Tet-transactivator regulatory elements to control the expression of a Plasmodium falciparum* gene within its’ native locus** Bonilla, Tonya D [] , Bonilla, J. Alfredo , Dame, John B Infectious Diseases and Pathology, University of Florida, Gainesville, FL, USA V Variable length perfect tandem repeat polymorphisms are widespread in the transcribed Plasmodium falciparum* genome** Tan, John C, Tan, Asako , Ferdig, Michael T [] Biological Sciences, University of Notre Dame, Notre Dame, USA Verification of the Gene Annotation in Toxoplasma gondii* by tandem mass-spectrometry** Rykunov, Dmitrij , Madrid, Carlos , Nieves, Edward , Che, Fa-Yun , Xiao, Hui , Kim, Kami [] , Weiss, Louis M, Angeletti, Ruth , Fiser, Andras Albert Einstein College of Medicine, Bronx, NY, USA W What does Rhomboid Serine Protease PyROM1 do in Plasmodium yoelii?* Vera, Iset M [1] , Mwakingwe, Agnes [1] , Coppi, Alida [2] , Sinnis, Photini [2] , Kim, Kami [,1] 1. Infectious Disease Medicine, Albert Einstein College of Medicine, Bronx, NY, United States 2. Medical Parasitology, NYU School of Medicine, New York, NY, United States WHO/TDR Drug Target Portfolio: Computational prioritization of potential drug targets for human parasitic diseases* Agüero, Fernán [1] , Berriman, Matthew [2] , Buckner, Frederick S. [3] , Hertz-Fowler, Christiane [2] , Nwaka, Solomon [4] , Pain, Arnab [2] , Ralph, Stuart A. [5] , Riechers, Aaron [3] , Roos, David S. [6] , Shanmugam, Dhanasekaran [6] , Suzuki, Takashi [2] , Van Voorhis, Wesley C. [,3] , Verlinde, Christophe L.M.J [3] 1. Univ. San Martín, Buenos Aires, Argentina 2. Sanger Inst., Hinxton, UK 3. Univ. Washington, Seattle, USA 4. WHO/TDR, Geneva, Switzerland 5. Univ Melbourne, Victoria, Australia 6. Univ. Pennsylvania, Philadelphia, USA Workflow-based genome annotation of Eimeria tenella* Wu, Xikun [1] , Rajandream, Marie-Adele [2] , Berriman, Matthew [2] , Gruber, Arthur [3] , Madeira, Alda Maria B.N. [3] , Guo, Yike [4] , Rivailler, Pierre [5] , Tomley, Fiona [,1] 1. Microbiology, Institute for Animal Health, Compton, U.K. 2. The Wellcome Trust Sanger Institute, Hinxton, U.K. 3. University of Sao Paulo, Sao Paulo , Brazil 4. Imperial College London, London, U.K. 5. Biological Sciences Department, University of South Carolina, Columbia, SC, U.S.A Y Yeast rescue of Plasmodium falciparum* syntaxin homologs** Parish, Lindsay [1] , Rayner, Julian [,2] 1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA 2. Department of Medicine, Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, AL, USA 283 abstract(s) listed*


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